Combination Chemotherapy in Treating Patients With Primary Peritoneal or Stage III Epithelial Ovarian Cancer

Completed · Phase 3

Conditions studied: Ovarian Cancer, Primary Peritoneal Cavity Cancer

In brief

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and giving drugs in different ways may kill more tumor cells. It is not yet known whether intravenous two-drug combination chemotherapy is more effective than intravenous and intraperitoneal infusions of three-drug combination chemotherapy for treating primary peritoneal or stage III epithelial ovarian cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of intravenous two-drug combination chemotherapy with intravenous and intraperitoneal three-drug combination chemotherapy in treating patients who have primary peritoneal or stage III epithelial ovarian cancer.

Key facts

Study ID

NCT00003322

Run by

Gynecologic Oncology Group

People needed

384

Starts

1998-03-01

Last updated by the study team

2013-05-27

Who can join

Age: any. Sex: female. Healthy volunteers: not accepted.

Where it is running

• CCOP - Greater Phoenix — Phoenix, Arizona, United States
• USC/Norris Comprehensive Cancer Center — Los Angeles, California, United States
• Jonsson Comprehensive Cancer Center, UCLA — Los Angeles, California, United States
• Chao Family Comprehensive Cancer Center — Orange, California, United States
• Women's Cancer Center — Palo Alto, California, United States
• University of Colorado Cancer Center — Denver, Colorado, United States
• Lombardi Cancer Center, Georgetown University — Washington D.C., District of Columbia, United States
• Walter Reed Army Medical Center — Washington D.C., District of Columbia, United States
• H. Lee Moffitt Cancer Center and Research Institute — Tampa, Florida, United States
• Emory University Hospital - Atlanta — Atlanta, Georgia, United States
• CCOP - Atlanta Regional — Atlanta, Georgia, United States
• MBCCOP - Hawaii — Honolulu, Hawaii, United States
• Rush-Presbyterian-St. Luke's Medical Center — Chicago, Illinois, United States
• University of Chicago Cancer Research Center — Chicago, Illinois, United States
• CCOP - Central Illinois — Decatur, Illinois, United States
• CCOP - Evanston — Evanston, Illinois, United States
• Indiana University Cancer Center — Indianapolis, Indiana, United States
• University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
• Albert B. Chandler Medical Center, University of Kentucky — Lexington, Kentucky, United States
• Johns Hopkins Oncology Center — Baltimore, Maryland, United States
• Medicine Branch — Bethesda, Maryland, United States
• Radiation Oncology Branch — Bethesda, Maryland, United States
• University of Massachusetts Memorial Medical Center — Worcester, Massachusetts, United States
• CCOP - Ann Arbor Regional — Ann Arbor, Michigan, United States
• University of Alabama Comprehensive Cancer Center — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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