Radiation Therapy Following Surgery to Remove Brain Metastases

Completed · Not applicable

Conditions studied: Metastatic Cancer

In brief

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Giving radiation therapy after surgery to remove brain metastases may decrease the amount of radiation required to treat brain metastases. PURPOSE: Pilot trial to study the effectiveness of radiation therapy following surgery to remove brain metastases.

Key facts

Study ID

NCT00003320

Run by

Jonsson Comprehensive Cancer Center

People needed

20

Starts

1997-03-01

Last updated by the study team

2020-08-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically confirmed cerebral metastases post surgical resection
• No greater than 3 cerebral metastases postresection
• Gross resection at operation as documented in operation note and postoperative MRI Patients must have current surgical sites that have not been previously irradiated
• No other indication for whole brain irradiation (i.e., multiple untreated metastases not suitable for single fraction stereotactic radiotherapy, leptomeningeal disease)
• Age: 18 and over
• Karnofsky 60-100%
• Life expectancy: At least 3 months
• Prior or concurrent required steroids allowed
• Prior stereotactic radiotherapy of cerebral metastases allowed provided no prior irradiation of current surgical sites
• Prior surgery of cerebral metastases allowed

You may not qualify if…

• severe asthma requiring therapy
• allergy to iodine or contrast media
• pregnant
• concurrent chemotherapy
• prior whole brain irradiation or focal irradiation to current sites of disease

Where it is running

• Jonsson Comprehensive Cancer Center, UCLA — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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