Tirapazamine Plus Cyclophosphamide in Treating Children With Refractory Solid Tumors

Completed · Phase 1

Conditions studied: Unspecified Childhood Solid Tumor, Protocol Specific

In brief

Phase I trial to study the effectiveness of tirapazamine plus cyclophosphamide in treating children who have refractory solid tumors. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.

Key facts

Study ID

NCT00003288

Run by

National Cancer Institute (NCI)

People needed

12

Starts

1998-08-01

Last updated by the study team

2013-02-05

Who can join

Age: any, up to 21. Sex: any. Healthy volunteers: not accepted.

Where it is running

• University of Alabama Comprehensive Cancer Center — Birmingham, Alabama, United States
• University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
• University of California San Diego Cancer Center — La Jolla, California, United States
• Lucile Packard Children's Hospital at Stanford — Palo Alto, California, United States
• Sylvester Cancer Center, University of Miami — Miami, Florida, United States
• Emory University Hospital - Atlanta — Atlanta, Georgia, United States
• Children's Memorial Hospital, Chicago — Chicago, Illinois, United States
• University of Kansas Medical Center — Kansas City, Kansas, United States
• Johns Hopkins Oncology Center — Baltimore, Maryland, United States
• Floating Hospital for Children — Boston, Massachusetts, United States
• Dana-Farber Cancer Institute — Boston, Massachusetts, United States
• Children's Hospital of Michigan — Detroit, Michigan, United States
• University of Mississippi Medical Center — Jackson, Mississippi, United States
• Cardinal Glennon Children's Hospital — St Louis, Missouri, United States
• Washington University School of Medicine — St Louis, Missouri, United States
• Hackensack University Medical Center — Hackensack, New Jersey, United States
• Roswell Park Cancer Institute — Buffalo, New York, United States
• State University of New York - Upstate Medical University — Syracuse, New York, United States
• Duke Comprehensive Cancer Center — Durham, North Carolina, United States
• Saint Jude Children's Research Hospital — Memphis, Tennessee, United States
• Simmons Cancer Center - Dallas — Dallas, Texas, United States
• Cook Children's Medical Center - Fort Worth — Fort Worth, Texas, United States
• Baylor College of Medicine — Houston, Texas, United States
• University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States
• Midwest Children's Cancer Center — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

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