Carboplatin and Vincristine Plus Radiation Therapy Followed By Adjuvant Chemotherapy in Treating Young Patients With Newly Diagnosed CNS Embryonal Tumors

Completed · Phase 2

Conditions studied: Brain Tumors, Central Nervous System Tumors, Neuroblastoma

In brief

RATIONALE: Drugs used in chemotherapy, such as carboplatin and vincristine, work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining carboplatin and vincristine with radiation therapy followed by adjuvant chemotherapy may kill more tumor cells. PURPOSE: Randomized phase II trial to study the effectiveness of combination chemotherapy plus radiation therapy followed adjuvant chemotherapy in treating young patients who have newly diagnosed high-risk CNS embryonal tumors.

Key facts

Study ID

NCT00003203

Run by

Children's Oncology Group

People needed

168

Starts

1998-03-01

Expected to finish

2012-03-01

Last updated by the study team

2013-08-23

Who can join

Age: 3 and older, up to 21. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Long Beach Memorial Medical Center — Long Beach, California, United States
• Children's Hospital Los Angeles — Los Angeles, California, United States
• Jonsson Comprehensive Cancer Center, UCLA — Los Angeles, California, United States
• Children's Hospital of Orange County — Orange, California, United States
• UCSF Cancer Center and Cancer Research Institute — San Francisco, California, United States
• Children's Hospital of Denver — Denver, Colorado, United States
• Children's National Medical Center — Washington D.C., District of Columbia, United States
• University of Chicago Cancer Research Center — Chicago, Illinois, United States
• Indiana University Cancer Center — Indianapolis, Indiana, United States
• University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
• University of Michigan Comprehensive Cancer Center — Ann Arbor, Michigan, United States
• CCOP - Kalamazoo — Kalamazoo, Michigan, United States
• University of Minnesota Cancer Center — Minneapolis, Minnesota, United States
• Mayo Clinic Cancer Center — Rochester, Minnesota, United States
• Children's Mercy Hospital — Kansas City, Missouri, United States
• University of Nebraska Medical Center — Omaha, Nebraska, United States
• St. Joseph's Hospital and Medical Center — Paterson, New Jersey, United States
• NYU School of Medicine's Kaplan Comprehensive Cancer Center — New York, New York, United States
• Memorial Sloan-Kettering Cancer Center — New York, New York, United States
• Herbert Irving Comprehensive Cancer Center — New York, New York, United States
• Lineberger Comprehensive Cancer Center, UNC — Chapel Hill, North Carolina, United States
• CCOP - Merit Care Hospital — Fargo, North Dakota, United States
• Children's Hospital Medical Center - Cincinnati — Cincinnati, Ohio, United States
• Ireland Cancer Center — Cleveland, Ohio, United States
• Children's Hospital of Columbus — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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