Surgery Plus Medroxyprogesterone in Preventing Endometrial Cancer

Stopped early · Phase 2

Conditions studied: Endometrial Cancer

In brief

RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of surgery with or without medroxyprogesterone may be an effective way to prevent the development of endometrial cancer in patients who have endometrial hyperplasia. PURPOSE: Phase II trial to compare the effectiveness of surgery alone with that of medroxyprogesterone followed by surgery in preventing endometrial cancer in patients who have endometrial hyperplasia.

Key facts

Study ID

NCT00003179

Run by

Gynecologic Oncology Group

People needed

360

Starts

1998-11-01

Last updated by the study team

2013-06-10

Who can join

Age: any. Sex: female. Healthy volunteers: not accepted.

Where it is running

• Arizona Cancer Center — Tucson, Arizona, United States
• Community Hospital of Los Gatos — Los Gatos, California, United States
• Chao Family Comprehensive Cancer Center — Orange, California, United States
• Walter Reed Army Medical Center — Washington D.C., District of Columbia, United States
• University of Chicago Cancer Research Center — Chicago, Illinois, United States
• Indiana University Cancer Center — Indianapolis, Indiana, United States
• Holden Comprehensive Cancer Center — Iowa City, Iowa, United States
• Albert B. Chandler Medical Center, University of Kentucky — Lexington, Kentucky, United States
• Marlene and Stewart Greenebaum Cancer Center, University of Maryland — Baltimore, Maryland, United States
• Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — Baltimore, Maryland, United States
• Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support — Bethesda, Maryland, United States
• University of Mississippi Medical Center — Jackson, Mississippi, United States
• Keesler Medical Center - Keesler AFB — Keesler Air Force Base, Mississippi, United States
• Ellis Fischel Cancer Center - Columbia — Columbia, Missouri, United States
• Washington University School of Medicine — St Louis, Missouri, United States
• Cooper Hospital/University Medical Center — Camden, New Jersey, United States
• State University of New York Health Sciences Center - Stony Brook — Stony Brook, New York, United States
• Duke Comprehensive Cancer Center — Durham, North Carolina, United States
• Comprehensive Cancer Center at Wake Forest University — Winston-Salem, North Carolina, United States
• Barrett Cancer Center — Cincinnati, Ohio, United States
• Cleveland Clinic Taussig Cancer Center — Cleveland, Ohio, United States
• Arthur G. James Cancer Hospital - Ohio State University — Columbus, Ohio, United States
• University of Oklahoma College of Medicine — Oklahoma City, Oklahoma, United States
• Abington Memorial Hospital — Abington, Pennsylvania, United States
• Milton S. Hershey Medical Center — Hershey, Pennsylvania, United States

Full record on ClinicalTrials.gov

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