Pilocarpine in Preventing Mucositis and Dry Mouth in Patients Receiving Radiation Therapy for Head and Neck Cancer
Completed · Phase 3 · Has a placebo group
Conditions studied: Head and Neck Cancer, Oral Complications
In brief
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs such as pilocarpine may protect normal cells from the side effects of radiation therapy. It is not yet known if pilocarpine may be effective in preventing mucositis and dry mouth in patients receiving radiation therapy for head and neck cancer. PURPOSE: Randomized, double-blinded, phase III trial to study the effectiveness of pilocarpine in preventing mucositis and dry mouth in patients receiving radiation therapy for head and neck cancer.
Key facts
- Study ID
- NCT00003139
- Run by
- Radiation Therapy Oncology Group
- People needed
- 249
- Starts
- 1998-03-01
- Expected to finish
- 2002-10-01
- Last updated by the study team
- 2015-11-17
Who can join
Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Alabama Comprehensive Cancer Center — Birmingham, Alabama, United States
- Huntsville Hospital System — Huntsville, Alabama, United States
- Urology Associates - Mobile AL — Mobile, Alabama, United States
- MBCCOP - University of South Alabama — Mobile, Alabama, United States
- Alabama Oncology, LLC — Montgomery, Alabama, United States
- Radiation Oncology Associates of West Alabama — Tuscallosa, Alabama, United States
- Providence Cancer Therapy Center — Anchorage, Alaska, United States
- Arizona Cancer Center — Tucson, Arizona, United States
- Providence Saint Joseph Medical Center - Burbank — Burbank, California, United States
- Mount Diablo Medical Center — Concord, California, United States
- Beckman Research Institute, City of Hope — Duarte, California, United States
- California Cancer Center — Fresno, California, United States
- Saint Agnes Cancer Center — Fresno, California, United States
- Glendale Memorial Hospital and Health Center — Glendale, California, United States
- Sutter Health Western Division Cancer Research Group — Greenbrae, California, United States
- Loma Linda University Medical Center — Loma Linda, California, United States
- Veterans Affairs Medical Center - Long Beach — Long Beach, California, United States
- Kaiser Permanente Medical Center - Los Angeles — Los Angeles, California, United States
- USC/Norris Comprehensive Cancer Center — Los Angeles, California, United States
- Jonsson Comprehensive Cancer Center, UCLA — Los Angeles, California, United States
- Veterans Affairs Outpatient Clinic - Martinez — Martinez, California, United States
- CCOP - Bay Area Tumor Institute — Oakland, California, United States
- Cancer Care Center — Pomona, California, United States
- Mercy Medical Center - Redding — Redding, California, United States
- Veterans Affairs Medical Center - Birmingham — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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