Radiation Therapy With or Without Cisplatin or Fluorouracil in Treating Patients With Cancer of the Cervix

Completed · Phase 3

Conditions studied: Cervical Cancer

In brief

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining radiation therapy and chemotherapy may kill more tumor cells. It is not known whether receiving radiation therapy plus cisplatin is more effective than receiving radiation therapy plus fluorouracil in treating patients with cancer of the cervix. PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy plus cisplatin or fluorouracil in treating patients with primary stage IIB, stage IIIB, or stage IVA cancer of the cervix.

Key facts

Study ID

NCT00003078

Run by

Gynecologic Oncology Group

People needed

870

Starts

1997-10-01

Last updated by the study team

2013-07-09

Who can join

Age: any. Sex: female. Healthy volunteers: not accepted.

Where it is running

• CCOP - Greater Phoenix — Phoenix, Arizona, United States
• USC/Norris Comprehensive Cancer Center — Los Angeles, California, United States
• Jonsson Comprehensive Cancer Center, UCLA — Los Angeles, California, United States
• Chao Family Comprehensive Cancer Center — Orange, California, United States
• Women's Cancer Center — Palo Alto, California, United States
• University of Colorado Cancer Center — Denver, Colorado, United States
• Vincent T. Lombardi Cancer Research Center, Georgetown University — Washington D.C., District of Columbia, United States
• Walter Reed Army Medical Center — Washington D.C., District of Columbia, United States
• Fred J. Woods Radiation Therapy Center/St. Joseph's Cancer Institute — Tampa, Florida, United States
• H. Lee Moffitt Cancer Center and Research Institute — Tampa, Florida, United States
• Emory University Hospital - Atlanta — Atlanta, Georgia, United States
• MBCCOP - Hawaii — Honolulu, Hawaii, United States
• Rush-Presbyterian-St. Luke's Medical Center — Chicago, Illinois, United States
• University of Chicago Cancer Research Center — Chicago, Illinois, United States
• CCOP - Central Illinois — Decatur, Illinois, United States
• CCOP - Evanston — Evanston, Illinois, United States
• Indiana University Cancer Center — Indianapolis, Indiana, United States
• University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
• Albert B. Chandler Medical Center, University of Kentucky — Lexington, Kentucky, United States
• Johns Hopkins Oncology Center — Baltimore, Maryland, United States
• Medicine Branch — Bethesda, Maryland, United States
• Radiation Oncology Branch — Bethesda, Maryland, United States
• University of Massachusetts Memorial Medical Center — Worcester, Massachusetts, United States
• CCOP - Ann Arbor Regional — Ann Arbor, Michigan, United States
• University of Alabama Comprehensive Cancer Center — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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