Enalapril in Treating Heart Damage Patients Who Received Anthracycline Chemotherapy for Childhood Cancer
Completed · Phase 3
Conditions studied: Cardiac Toxicity, Unspecified Childhood Solid Tumor, Protocol Specific
In brief
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Chemoprotective drugs, such as enalapril, may protect normal cells from the toxic effects of chemotherapy. It is not known whether enalapril is more effective than a placebo in treating heart damage in patients who received anthracycline chemotherapy for childhood cancer. PURPOSE: Randomized double-blinded phase III trial to compare the effectiveness of enalapril with a placebo in treating heart damage in patients who received anthracycline chemotherapy for childhood cancer.
Key facts
- Study ID
- NCT00003070
- Run by
- Children's Oncology Group
- People needed
- 13
- Starts
- 2000-09-01
- Expected to finish
- 2007-03-01
- Last updated by the study team
- 2014-08-05
Who can join
Age: 8 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- MBCCOP - Gulf Coast — Mobile, Alabama, United States
- University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
- University of California San Diego Cancer Center — La Jolla, California, United States
- Lucile Packard Children's Hospital at Stanford — Palo Alto, California, United States
- University of California Davis Medical Center — Sacramento, California, United States
- Yale Comprehensive Cancer Center — New Haven, Connecticut, United States
- Walter Reed Army Medical Center — Washington D.C., District of Columbia, United States
- Shands Hospital and Clinics, University of Florida — Gainesville, Florida, United States
- Sylvester Cancer Center, University of Miami — Miami, Florida, United States
- Miami Children's Hospital — Miami, Florida, United States
- CCOP - Florida Pediatric — Tampa, Florida, United States
- Emory University Hospital - Atlanta — Atlanta, Georgia, United States
- Cancer Research Center of Hawaii — Honolulu, Hawaii, United States
- Children's Memorial Hospital, Chicago — Chicago, Illinois, United States
- University of Kansas Medical Center — Kansas City, Kansas, United States
- CCOP - Wichita — Wichita, Kansas, United States
- MBCCOP - LSU Health Sciences Center — New Orleans, Louisiana, United States
- CCOP - Ochsner — New Orleans, Louisiana, United States
- Ochsner Clinic — New Orleans, Louisiana, United States
- Marlene & Stewart Greenebaum Cancer Center, University of Maryland — Baltimore, Maryland, United States
- Johns Hopkins Oncology Center — Baltimore, Maryland, United States
- Boston Floating Hospital Infants and Children — Boston, Massachusetts, United States
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States
- University of Massachusetts Memorial Medical Center — Worcester, Massachusetts, United States
- University of Alabama at Birmingham Comprehensive Cancer Center — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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