Octreotide Compared With Loperamide Hydrochloride for Chemotherapy-Related Diarrhea in Patients With Colorectal Cancer

Completed · Phase 3

Conditions studied: Colorectal Cancer, Diarrhea

In brief

RATIONALE: Drugs such as octreotide and loperamide hydrochloride use different ways to relieve the diarrhea caused by chemotherapy. PURPOSE: Randomized phase III trial to compare the effectiveness of octreotide with loperamide hydrochloride for the treatment of chemotherapy-related diarrhea in patients who have colorectal cancer.

Key facts

Study ID

NCT00003057

Run by

Eastern Cooperative Oncology Group

People needed

500

Starts

1997-03-26

Last updated by the study team

2023-06-18

Who can join

Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.

Where it is running

• University of California San Diego Cancer Center — La Jolla, California, United States
• UCSF Cancer Center and Cancer Research Institute — San Francisco, California, United States
• CCOP - Christiana Care Health Services — Wilmington, Delaware, United States
• Walter Reed Army Medical Center — Washington D.C., District of Columbia, United States
• CCOP - Mount Sinai Medical Center — Miami Beach, Florida, United States
• University of Illinois at Chicago Health Sciences Center — Chicago, Illinois, United States
• University of Chicago Cancer Research Center — Chicago, Illinois, United States
• University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
• Marlene & Stewart Greenebaum Cancer Center, University of Maryland — Baltimore, Maryland, United States
• Dana-Farber Cancer Institute — Boston, Massachusetts, United States
• University of Massachusetts Memorial Medical Center — Worcester, Massachusetts, United States
• University of Minnesota Cancer Center — Minneapolis, Minnesota, United States
• Ellis Fischel Cancer Center - Columbia — Columbia, Missouri, United States
• Barnes-Jewish Hospital — St Louis, Missouri, United States
• University of Nebraska Medical Center — Omaha, Nebraska, United States
• CCOP - Southern Nevada Cancer Research Foundation — Las Vegas, Nevada, United States
• Norris Cotton Cancer Center — Lebanon, New Hampshire, United States
• CCOP - North Shore University Hospital — Manhasset, New York, United States
• North Shore University Hospital — Manhasset, New York, United States
• Memorial Sloan-Kettering Cancer Center — New York, New York, United States
• New York Presbyterian Hospital - Cornell Campus — New York, New York, United States
• Mount Sinai Medical Center, NY — New York, New York, United States
• CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C. — Syracuse, New York, United States
• State University of New York - Upstate Medical University — Syracuse, New York, United States
• Lineberger Comprehensive Cancer Center, UNC — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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