ONCONASE Plus Doxorubicin Versus Doxorubicin Alone For Patients With Malignant Pleural or Peritoneal Mesothelioma Who Have Had No More Than One Prior Chemotherapy Regimen

Status unconfirmed · Phase 3

Conditions studied: Malignant Mesothelioma

In brief

RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether Onconase plus doxorubicin is more effective than doxorubicin alone in treating patients with malignant mesothelioma. PURPOSE: This randomized phase III trial is studying doxorubicin alone to see how well it works compared to doxorubicin and Onconase in treating patients with malignant mesothelioma.

Key facts

Study ID

NCT00003034

Run by

Alfacell

People needed

300

Starts

1997-05-01

Last updated by the study team

2013-11-06

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• CCOP - Northern Indiana CR Consortium — South Bend, Indiana, United States
• Greenebaum Cancer Center at University of Maryland Medical Center — Baltimore, Maryland, United States
• Spectrum Health Hospital - Butterworth Campus — Grand Rapids, Michigan, United States
• CCOP - Duluth — Duluth, Minnesota, United States
• Missouri Cancer Care, PC at St. Joseph Health Center - St. Charles — Saint Charles, Missouri, United States
• Methodist Estabrook Cancer Center — Omaha, Nebraska, United States
• University of New Mexico Cancer Research and Treatment Center — Albuquerque, New Mexico, United States
• Asklepios Fachkliniken Muenchen-Gauting — Gauting, Germany
• Hospital Grosshansdorf — Großhansdorf, Germany
• Asklepios Klinik St. Georg — Hamburg, Germany
• Asklepios Klinik Harburg — Hamburg, Germany
• Klinikum Rechts Der Isar - Technische Universitaet Muenchen — Munich, Germany
• Istituto Nazionale per la Ricerca sul Cancro — Genoa, Italy
• Ospedale San Martino — Genoa, Italy
• Fondazione I.R.C.C.S. Policlinico San Matteo — Pavia, Italy
• Medical University of Gdansk — Gdansk, Poland
• University School of Medical Sciences — Poznan, Poland
• Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology — Warsaw, Poland
• Klinika Chrorob Pluc I Gruzlicy — Zabrze, Poland

Full record on ClinicalTrials.gov

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