Combination Chemotherapy With or Without Interleukin-2 and Interferon Alfa in Treating Patients With Metastatic Melanoma

Completed · Phase 3

Conditions studied: Melanoma (Skin)

In brief

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Interleukin-2 may stimulate a person's white blood cells to kill melanoma cells. Interferon alfa may interfere with the growth of tumor cells. It is not yet known whether combination chemotherapy plus interleukin-2 and interferon alfa is more effective than combination chemotherapy alone for metastatic melanoma. PURPOSE: Randomized phase III trial to compare combination chemotherapy with or without interleukin-2 and interferon alfa in treating patients who have metastatic melanoma that cannot be treated by surgery.

Key facts

Study ID

NCT00003027

Run by

Eastern Cooperative Oncology Group

People needed

482

Starts

1997-11-13

Last updated by the study team

2023-06-22

Who can join

Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.

Where it is running

• CCOP - Greater Phoenix — Phoenix, Arizona, United States
• Veterans Affairs Medical Center - Phoenix (Carl T. Hayden) — Phoenix, Arizona, United States
• Veterans Affairs Medical Center - Tucson — Tucson, Arizona, United States
• Arizona Cancer Center — Tucson, Arizona, United States
• University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
• Veterans Affairs Medical Center - Little Rock (McClellan) — Little Rock, Arkansas, United States
• Cancer Center and Beckman Research Institute, City of Hope — Duarte, California, United States
• USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
• Veterans Affairs Medical Center - West Los Angeles — Los Angeles, California, United States
• Jonsson Comprehensive Cancer Center, UCLA — Los Angeles, California, United States
• Veterans Affairs Outpatient Clinic - Martinez — Martinez, California, United States
• CCOP - Bay Area Tumor Institute — Oakland, California, United States
• Chao Family Comprehensive Cancer Center — Orange, California, United States
• University of California Davis Medical Center — Sacramento, California, United States
• UCSF Cancer Center and Cancer Research Institute — San Francisco, California, United States
• CCOP - Santa Rosa Memorial Hospital — Santa Rosa, California, United States
• David Grant Medical Center — Travis Air Force Base, California, United States
• University of Colorado Cancer Center — Denver, Colorado, United States
• Veterans Affairs Medical Center - Denver — Denver, Colorado, United States
• CCOP - Atlanta Regional — Atlanta, Georgia, United States
• Dwight David Eisenhower Army Medical Center — Fort Gordon, Georgia, United States
• Cancer Research Center of Hawaii — Honolulu, Hawaii, United States
• MBCCOP - University of Illinois at Chicago — Chicago, Illinois, United States
• Veterans Affairs Medical Center - Chicago (Westside Hospital) — Chicago, Illinois, United States
• MBCCOP - Gulf Coast — Mobile, Alabama, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.