Chemotherapy With or Without Total-Body Irradiation Prior to Bone Marrow Transplantation in Treating Children With Acute Lymphoblastic Leukemia
Stopped early · Phase 3
Conditions studied: Leukemia
In brief
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with bone marrow transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells. Radiation therapy uses high-energy x-rays to damage cancer cells. Combining chemotherapy, radiation therapy, and bone marrow transplantation may kill more cancer cells. PURPOSE: Randomized phase III trial to compare high-dose chemotherapy with or without total-body irradiation before bone marrow transplantation in treating children with acute lymphoblastic leukemia.
Key facts
- Study ID
- NCT00002961
- Run by
- Children's Hospital of Philadelphia
- People needed
- 43
- Starts
- 1995-10-01
- Expected to finish
- 2001-02-01
- Last updated by the study team
- 2013-10-16
Who can join
Age: any, up to 21. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Alabama Comprehensive Cancer Center — Birmingham, Alabama, United States
- Children's Hospital and Health Center — San Diego, California, United States
- Nemours Children's Clinic — Jacksonville, Florida, United States
- All Children's Hospital — St. Petersburg, Florida, United States
- University of Chicago Cancer Research Center — Chicago, Illinois, United States
- Albert B. Chandler Medical Center, University of Kentucky — Lexington, Kentucky, United States
- Louisiana State University School of Medicine — New Orleans, Louisiana, United States
- Tulane University School of Medicine — New Orleans, Louisiana, United States
- Children's Mercy Hospital — Kansas City, Missouri, United States
- Cardinal Glennon Children's Hospital — St Louis, Missouri, United States
- Washington University Medical Center — St Louis, Missouri, United States
- Ireland Cancer Center — Cleveland, Ohio, United States
- Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
- Palmetto Richland Memorial Hospital — Columbia, South Carolina, United States
- South Texas Cancer Institute — San Antonio, Texas, United States
- University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States
- Huntsman Cancer Institute — Salt Lake City, Utah, United States
- Alberta Children's Hospital — Calgary, Alberta, Canada
Full record on ClinicalTrials.gov
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