Combination Chemotherapy Plus PSC 833 Followed by Interleukin-2 in Treating Patients With Acute Myelogenous Leukemia
Completed · Phase 1/Phase 2
Conditions studied: Leukemia
In brief
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Some cancers may become resistant to chemotherapy drugs. Combining PSC 833 with chemotherapy may reduce resistance to the drugs and allow the cancer cells to be killed. Interleukin-2 may stimulate a person's white blood cells to kill leukemia cells. PURPOSE: Phase I/II trial to study the effectiveness of combination chemotherapy plus PSC 833 followed by additional chemotherapy or peripheral stem cell transplantation and interleukin-2 in treating patients with untreated acute myelogenous leukemia.
Key facts
- Study ID
- NCT00002925
- Run by
- National Cancer Institute (NCI)
- People needed
- 410
- Starts
- 1997-02-01
- Expected to finish
- 2010-06-01
- Last updated by the study team
- 2012-11-30
Who can join
Age: 15 and older, up to 59. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of California San Diego Cancer Center — La Jolla, California, United States
- UCSF Cancer Center and Cancer Research Institute — San Francisco, California, United States
- CCOP - Christiana Care Health Services — Wilmington, Delaware, United States
- Walter Reed Army Medical Center — Washington D.C., District of Columbia, United States
- CCOP - Mount Sinai Medical Center — Miami Beach, Florida, United States
- University of Illinois at Chicago Health Sciences Center — Chicago, Illinois, United States
- University of Chicago Cancer Research Center — Chicago, Illinois, United States
- University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
- Marlene & Stewart Greenebaum Cancer Center, University of Maryland — Baltimore, Maryland, United States
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States
- University of Massachusetts Memorial Medical Center — Worcester, Massachusetts, United States
- Ellis Fischel Cancer Center - Columbia — Columbia, Missouri, United States
- Barnes-Jewish Hospital — St Louis, Missouri, United States
- University of Nebraska Medical Center — Omaha, Nebraska, United States
- CCOP - Southern Nevada Cancer Research Foundation — Las Vegas, Nevada, United States
- Norris Cotton Cancer Center — Lebanon, New Hampshire, United States
- Roswell Park Cancer Institute — Buffalo, New York, United States
- CCOP - North Shore University Hospital — Manhasset, New York, United States
- North Shore University Hospital — Manhasset, New York, United States
- Memorial Sloan-Kettering Cancer Center — New York, New York, United States
- New York Presbyterian Hospital - Cornell Campus — New York, New York, United States
- Mount Sinai Medical Center, NY — New York, New York, United States
- CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C. — Syracuse, New York, United States
- State University of New York - Upstate Medical University — Syracuse, New York, United States
- Lineberger Comprehensive Cancer Center, UNC — Chapel Hill, North Carolina, United States
Full record on ClinicalTrials.gov
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