Combination Chemotherapy Plus PSC-833 in Treating Children With Refractory or Relapsed Acute Leukemia

Completed · Phase 1

Conditions studied: Leukemia

In brief

Phase I trial to study the effectiveness of PSC-833 plus etoposide and mitoxantrone in treating children who have refractory or relapsed acute leukemia. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Some cancers become resistant to chemotherapy drugs. Combining PSC-833 with chemotherapy may reduce resistance to the drug and allow more cancer cells to be killed.

Key facts

Study ID

NCT00002912

Run by

National Cancer Institute (NCI)

People needed

3

Starts

1997-01-01

Last updated by the study team

2013-02-01

Who can join

Age: any, up to 21. Sex: any. Healthy volunteers: not accepted.

Where it is running

• University of California San Diego Cancer Center — La Jolla, California, United States
• Children's Hospital Los Angeles — Los Angeles, California, United States
• Jonsson Comprehensive Cancer Center, UCLA — Los Angeles, California, United States
• City of Hope National Medical Center — Los Angeles, California, United States
• Children's Hospital of Orange County — Orange, California, United States
• UCSF Cancer Center and Cancer Research Institute — San Francisco, California, United States
• Stanford University Medical Center — Stanford, California, United States
• Children's National Medical Center — Washington D.C., District of Columbia, United States
• University of Florida Health Science Center — Gainesville, Florida, United States
• Emory University Hospital - Atlanta — Atlanta, Georgia, United States
• Robert H. Lurie Comprehensive Cancer Center, Northwestern University — Chicago, Illinois, United States
• Children's Memorial Hospital, Chicago — Chicago, Illinois, United States
• Indiana University Cancer Center — Indianapolis, Indiana, United States
• University of Kansas Medical Center — Kansas City, Kansas, United States
• Johns Hopkins Oncology Center — Baltimore, Maryland, United States
• Boston Floating Hospital Infants and Children — Boston, Massachusetts, United States
• Dana-Farber Cancer Institute — Boston, Massachusetts, United States
• University of Michigan Comprehensive Cancer Center — Ann Arbor, Michigan, United States
• Children's Hospital of Michigan — Detroit, Michigan, United States
• University of Minnesota Cancer Center — Minneapolis, Minnesota, United States
• Mayo Clinic Cancer Center — Rochester, Minnesota, United States
• University of Mississippi Medical Center — Jackson, Mississippi, United States
• Children's Mercy Hospital — Kansas City, Missouri, United States
• Cardinal Glennon Children's Hospital — St Louis, Missouri, United States
• University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

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