Radiation Therapy Plus Combination Chemotherapy in Treating Children With Medulloblastoma
Completed · Phase 3
Conditions studied: Brain Tumors, Central Nervous System Tumors
In brief
RATIONALE: Radiation therapy uses high energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining radiation therapy with chemotherapy may kill more tumor cells. It is not yet known which chemotherapy regimen is more effective when combined with radiation therapy for treating medulloblastoma. PURPOSE: Randomized phase III trial to compare two combination chemotherapy treatments plus radiation therapy in treating children with newly diagnosed medulloblastoma.
Key facts
- Study ID
- NCT00002875
- Run by
- Children's Oncology Group
- People needed
- 421
- Starts
- 1996-12-01
- Expected to finish
- 2011-01-01
- Last updated by the study team
- 2014-08-01
Who can join
Age: 3 and older, up to 22. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Long Beach Memorial Medical Center — Long Beach, California, United States
- Children's Hospital Los Angeles — Los Angeles, California, United States
- Jonsson Comprehensive Cancer Center, UCLA — Los Angeles, California, United States
- Children's Hospital of Orange County — Orange, California, United States
- UCSF Cancer Center and Cancer Research Institute — San Francisco, California, United States
- Children's Hospital of Denver — Denver, Colorado, United States
- Children's National Medical Center — Washington D.C., District of Columbia, United States
- University of Chicago Cancer Research Center — Chicago, Illinois, United States
- Indiana University Cancer Center — Indianapolis, Indiana, United States
- University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
- Via Christi Regional Medical Center — Wichita, Kansas, United States
- MBCCOP - LSU Medical Center — New Orleans, Louisiana, United States
- University of Michigan Comprehensive Cancer Center — Ann Arbor, Michigan, United States
- University of Minnesota Cancer Center — Minneapolis, Minnesota, United States
- Mayo Clinic Cancer Center — Rochester, Minnesota, United States
- Children's Mercy Hospital — Kansas City, Missouri, United States
- University of Nebraska Medical Center — Omaha, Nebraska, United States
- St. Joseph's Hospital and Medical Center — Paterson, New Jersey, United States
- NYU School of Medicine's Kaplan Comprehensive Cancer Center — New York, New York, United States
- Memorial Sloan-Kettering Cancer Center — New York, New York, United States
- Herbert Irving Comprehensive Cancer Center — New York, New York, United States
- Lineberger Comprehensive Cancer Center, UNC — Chapel Hill, North Carolina, United States
- Children's Hospital Medical Center - Cincinnati — Cincinnati, Ohio, United States
- Ireland Cancer Center — Cleveland, Ohio, United States
- Children's Hospital of Columbus — Columbus, Ohio, United States
Full record on ClinicalTrials.gov
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