Radiation Therapy With or Without Bicalutamide for Recurrent pT3N0 Prostate Cancer After Radical Prostatectomy
Completed · Phase 3 · Has a placebo group
Conditions studied: Prostate Cancer
In brief
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Androgens can stimulate the growth of prostate cancer cells. Hormone therapy using bicalutamide may fight prostate cancer by reducing the production of androgens. It is not yet known if radiation therapy is more effective with or without bicalutamide for prostate cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy with or without bicalutamide in treating patients who have stage II or stage III prostate cancer and elevated prostate-specific antigen (PSA) levels following radical prostatectomy.
Key facts
- Study ID
- NCT00002874
- Run by
- Radiation Therapy Oncology Group
- People needed
- 840
- Starts
- 1998-02-01
- Expected to finish
- 2022-05-20
- Last updated by the study team
- 2022-06-15
Who can join
Age: any. Sex: male. Healthy volunteers: not accepted.
Where it is running
- Comprehensive Cancer Institute of Huntsville — Huntsville, Alabama, United States
- Huntsville Hospital System — Huntsville, Alabama, United States
- MBCCOP - Gulf Coast — Mobile, Alabama, United States
- Alabama Oncology, LLC — Montgomery, Alabama, United States
- Radiation Oncology Associates of West Alabama — Tuscaloosa, Alabama, United States
- Foundation for Cancer Research and Education — Phoenix, Arizona, United States
- Mount Diablo Medical Center — Concord, California, United States
- City of Hope Comprehensive Cancer Center — Duarte, California, United States
- Saint Agnes Cancer Center — Fresno, California, United States
- California Cancer Center — Fresno, California, United States
- Sutter Health West Cancer Research Group — Greenbrae, California, United States
- Loma Linda University Medical Center — Loma Linda, California, United States
- Veterans Affairs Medical Center - Long Beach — Long Beach, California, United States
- Jonsson Comprehensive Cancer Center, UCLA — Los Angeles, California, United States
- USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
- CCOP - Bay Area Tumor Institute — Oakland, California, United States
- Huntington Cancer Center — Pasadena, California, United States
- Cancer Care Center — Pomona, California, United States
- Radiation Oncology Center - Sacramento — Sacramento, California, United States
- Radiation Medical Group, Inc. — San Diego, California, United States
- UCSF Cancer Center and Cancer Research Institute — San Francisco, California, United States
- O'Connor Hospital — San Jose, California, United States
- CCOP - Santa Rosa Memorial Hospital — Santa Rosa, California, United States
- David Grant Medical Center — Travis Air Force Base, California, United States
- University of Alabama at Birmingham Comprehensive Cancer Center — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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