Chemotherapy Followed by Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin's Disease
Completed · Phase 3
Conditions studied: Cardiac Toxicity, Lymphoma
In brief
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells. Combining chemotherapy with radiation therapy may kill more cancer cells. It is not yet known if chemotherapy is more effective with or without dexrazoxane for Hodgkin's disease. PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy, with or without dexrazoxane, followed by radiation therapy in treating young patients with newly diagnosed stage I, stage II, or stage III Hodgkin's disease.
Key facts
- Study ID
- NCT00002827
- Run by
- Children's Oncology Group
- People needed
- 294
- Starts
- 1996-10-01
- Expected to finish
- 2008-06-01
- Last updated by the study team
- 2013-08-26
Who can join
Age: any, up to 21. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Long Beach Memorial Medical Center — Long Beach, California, United States
- Children's Hospital Los Angeles — Los Angeles, California, United States
- Jonsson Comprehensive Cancer Center, UCLA — Los Angeles, California, United States
- Children's Hospital of Orange County — Orange, California, United States
- UCSF Cancer Center and Cancer Research Institute — San Francisco, California, United States
- David Grant Medical Center — Travis Air Force Base, California, United States
- Children's Hospital of Denver — Denver, Colorado, United States
- Children's National Medical Center — Washington D.C., District of Columbia, United States
- University of Chicago Cancer Research Center — Chicago, Illinois, United States
- Indiana University Cancer Center — Indianapolis, Indiana, United States
- University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
- University of Michigan Comprehensive Cancer Center — Ann Arbor, Michigan, United States
- CCOP - Kalamazoo — Kalamazoo, Michigan, United States
- University of Minnesota Cancer Center — Minneapolis, Minnesota, United States
- Mayo Clinic Cancer Center — Rochester, Minnesota, United States
- Children's Mercy Hospital - Kansas City — Kansas City, Missouri, United States
- University of Nebraska Medical Center — Omaha, Nebraska, United States
- Cancer Institute of New Jersey — New Brunswick, New Jersey, United States
- Kaplan Cancer Center — New York, New York, United States
- Memorial Sloan-Kettering Cancer Center — New York, New York, United States
- Herbert Irving Comprehensive Cancer Center — New York, New York, United States
- Lineberger Comprehensive Cancer Center, UNC — Chapel Hill, North Carolina, United States
- Veterans Affairs Medical Center - Fargo — Fargo, North Dakota, United States
- CCOP - Merit Care Hospital — Fargo, North Dakota, United States
- Children's Hospital Medical Center - Cincinnati — Cincinnati, Ohio, United States
Full record on ClinicalTrials.gov
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