Radiation Therapy and Combination Chemotherapy in Treating Patients With Stage III or Stage IV Head and Neck Cancer
Completed · Phase 2
Conditions studied: Squamous Neck Carcinoma of the Head and Neck Cancer (SCCHN)
In brief
PURPOSE: Randomized phase 2 trial to compare the effectiveness of chemo-radiation therapy (RT + cisplatin + 5-FU) with or without tirapazamine for the treatment of patients with stage III or IV squamous cell carcinomas of the head and neck cancer (SCCHN). RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. Radiation therapy uses high-energy x-rays to damage tumor cells. Tirapazamine may increase the effectiveness of chemotherapy and radiation therapy by making tumor cells more sensitive to therapy.
Key facts
- Study ID
- NCT00002774
- Run by
- Stanford University
- People needed
- 63
- Starts
- 1996-06-01
- Expected to finish
- 2005-06-01
- Last updated by the study team
- 2014-06-20
Who can join
Age: 17 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Veterans Affairs Medical Center - Palo Alto — Palo Alto, California, United States
- Stanford University Medical Center — Stanford, California, United States
Full record on ClinicalTrials.gov
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