Antifungal Therapy for Fever and Neutropenia in Patients Receiving Treatment for Hematologic Cancer

Completed · Phase 3

Conditions studied: Chronic Myeloproliferative Disorders, Infection, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes

In brief

RATIONALE: Antifungal therapy with liposomal nystatin may reduce fever and neutropenia in patients undergoing treatment for hematologic cancer. It is not yet known whether liposomal nystatin is more effective than standard amphotericin B in treating patients with fever and neutropenia who are receiving chemotherapy for hematologic cancer or bone marrow transplantation for leukemia. PURPOSE: Randomized phase III trial to study the effectiveness of liposomal nystatin compared with standard amphotericin B to treat fever and neutropenia in patients receiving chemotherapy for hematologic cancer or bone marrow transplantation for leukemia.

Key facts

Study ID

NCT00002742

Run by

Aronex Pharmaceuticals

Starts

1996-01-01

Expected to finish

2007-09-01

Last updated by the study team

2013-03-26

Who can join

Age: 2 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Holt-Krock Clinic — Fort Smith, Arkansas, United States
• Arkansas Children's Hospital — Little Rock, Arkansas, United States
• Office of Rosalda Rodriguez, M.D. — Chula Vista, California, United States
• Beckman Research Institute, City of Hope — Duarte, California, United States
• Eisenhower Medical Center — Rancho Mirage, California, United States
• University of Colorado Cancer Center — Denver, Colorado, United States
• New Britain General Hospital — New Britain, Connecticut, United States
• Vincent T. Lombardi Cancer Research Center, Georgetown University — Washington D.C., District of Columbia, United States
• Sylvester Cancer Center, University of Miami — Miami, Florida, United States
• Tampa Children's Hospital — Tampa, Florida, United States
• Rush-Presbyterian-St. Luke's Medical Center — Chicago, Illinois, United States
• St. John's Pavilion - Springfield Clinic Research Department — Springfield, Illinois, United States
• University of Kansas Medical Center — Kansas City, Kansas, United States
• Lake Charles Medical and Surgical Clinic — Lake Charles, Louisiana, United States
• Johns Hopkins Oncology Center — Baltimore, Maryland, United States
• Dana-Farber Cancer Institute — Boston, Massachusetts, United States
• Boston University School of Medicine — Boston, Massachusetts, United States
• Barbara Ann Karmanos Cancer Institute — Detroit, Michigan, United States
• Henry Ford Hospital — Detroit, Michigan, United States
• United Hospital — Saint Paul, Minnesota, United States
• Columbia Comprehensive Cancer Care Clinic — Columbia, Missouri, United States
• University of Missouri-Columbia Hospital and Clinics — Columbia, Missouri, United States
• Children's Mercy Hospital - Kansas City — Kansas City, Missouri, United States
• Veterans Affairs Medical Center - Kansas City — Kansas City, Missouri, United States
• Veterans Affairs Medical Center - Phoenix (Hayden) — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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