SWOG-9321 Melphalan, TBI, and Transplant vs Combo Chemo in Untreated Myeloma
Completed · Phase 3
Conditions studied: Multiple Myeloma
In brief
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells. Combining chemotherapy and radiation therapy with peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy and radiation therapy and kill more cancer cells. It is not yet known which treatment regimen is more effective for multiple myeloma. PURPOSE: Randomized phase III trial to compare the effectiveness of melphalan, total-body irradiation, and peripheral stem cell transplantation with that of combination chemotherapy in treating patients who have previously untreated multiple myeloma.
Key facts
- Study ID
- NCT00002548
- Run by
- SWOG Cancer Research Network
- People needed
- 899
- Starts
- 1994-01-01
- Expected to finish
- 2006-11-01
- Last updated by the study team
- 2015-03-06
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
Where it is running
- CCOP - Scottsdale Oncology Program — Scottsdale, Arizona, United States
- CCOP - Colorado Cancer Research Program, Inc. — Denver, Colorado, United States
- H. Lee Moffitt Cancer Center and Research Institute — Tampa, Florida, United States
- Robert H. Lurie Comprehensive Cancer Center, Northwestern University — Chicago, Illinois, United States
- Veterans Affairs Medical Center - Lakeside Chicago — Chicago, Illinois, United States
- CCOP - Evanston — Evanston, Illinois, United States
- CCOP - Illinois Oncology Research Association — Peoria, Illinois, United States
- CCOP - Carle Cancer Center — Urbana, Illinois, United States
- Indiana University Cancer Center — Indianapolis, Indiana, United States
- Veterans Affairs Medical Center - Indianapolis (Roudebush) — Indianapolis, Indiana, United States
- CCOP - Iowa Oncology Research Association — Des Moines, Iowa, United States
- CCOP - Ochsner — New Orleans, Louisiana, United States
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — Baltimore, Maryland, United States
- New England Medical Center Hospital — Boston, Massachusetts, United States
- Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
- CCOP - Ann Arbor Regional — Ann Arbor, Michigan, United States
- CCOP - Kalamazoo — Kalamazoo, Michigan, United States
- CCOP - Duluth — Duluth, Minnesota, United States
- University of Minnesota Cancer Center — Minneapolis, Minnesota, United States
- Mayo Clinic Cancer Center — Rochester, Minnesota, United States
- CCOP - Metro-Minnesota — Saint Louis Park, Minnesota, United States
- Veterans Affairs Medical Center - New York — New York, New York, United States
- NYU School of Medicine's Kaplan Comprehensive Cancer Center — New York, New York, United States
- University of Rochester Cancer Center — Rochester, New York, United States
- Albert Einstein Comprehensive Cancer Center — The Bronx, New York, United States
Full record on ClinicalTrials.gov
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