A Study to Compare the Safety and Effectiveness of Indinavir Combined With Stavudine and Lamivudine

Paused · Phase 2

Conditions studied: HIV Infections

In brief

This study will see how safe and effective against HIV the drugs L-756423 plus indinavir (IDV) are compared to just IDV when taken with stavudine (d4T) and lamivudine (3TC). The study will also see whether taking 1 large dose of L-756423/IDV once a day is as safe and effective as taking 2 smaller doses twice a day.

Key facts

Study ID

NCT00002424

Run by

Merck Sharp & Dohme LLC

People needed

186

Last updated by the study team

2005-06-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• You may be eligible for this trial if you:
• Have HIV infection.
• Have levels of CD4 cells of 100 cells/mm3 or greater.
• Have a viral load of 10,000 copies/ml or greater.
• Are 18 years of age or older.

You may not qualify if…

• You may not be eligible for this trial if you:
• Have ever taken anti-HIV drugs.

Where it is running

• UCLA School of Medicine / Ctr for Research and Education — Los Angeles, California, United States
• Georgetown Univ Med Ctr — Washington D.C., District of Columbia, United States
• ViRx / Dupont Circle Physicians Group — Washington D.C., District of Columbia, United States
• Associates in Research — Fort Myers, Florida, United States
• Univ of Miami School of Medicine — Miami, Florida, United States
• Grady Mem Hosp — Atlanta, Georgia, United States
• Rush Presbyterian - Saint Luke's Med Ctr — Chicago, Illinois, United States
• The CORE Ctr — Chicago, Illinois, United States
• Univ of Kentucky Med Ctr — Lexington, Kentucky, United States
• Univ of Kentucky — Lexington, Kentucky, United States
• Beth Israel Deaconess Med Ctr — Boston, Massachusetts, United States
• Henry Ford Hosp — Detroit, Michigan, United States
• NYU Med Ctr / C & D Building — New York, New York, United States
• Aaron Diamond AIDS Rsch Ctr / Rockefeller Univ — New York, New York, United States
• SUNY at Stony Brook / Div of Infectious Disease — Stony Brook, New York, United States
• The Miriam Hosp — Providence, Rhode Island, United States

Full record on ClinicalTrials.gov

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