A Study of Lobucavir in Patients With AIDS

Completed · Not applicable

Conditions studied: Cytomegalovirus Infections, HIV Infections

In brief

The purpose of this study is to see if lobucavir is a safe and effective treatment for cytomegalovirus in patients with AIDS.

Key facts

Study ID

NCT00002352

Run by

Bristol-Myers Squibb

People needed

30

Last updated by the study team

2007-10-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Concurrent Medication:
• Allowed:
• Aerosolized pentamidine.
• TMP / SMX.
• Isoniazid.
• Dapsone.
• Fluconazole.
• Ketoconazole.
• Rifabutin.
• Fluoxetine HCl.
• Acetaminophen.
• Antacids.
• Metamucil.
• Multivitamins.
• Other drugs with approval from sponsor.
• Patients must have:
• AIDS.
• CD4 count < 200 cells/mm3.
• Cytomegalovirus ( CMV ) viruria and virosemenia.
• No evidence of intraocular CMV.

You may not qualify if…

• Co-existing Condition:
• Patients with the following symptoms or conditions are excluded:
• Acute or chronic cardiovascular, pulmonary, renal, hepatic, pancreatic, hematologic, endocrine, neurological, or other unstable illness.
• Inability to take oral medication.
• Allergy to nucleoside analogs.
• Diarrheal illness.
• Poor venous access.
• Positive test for drugs of abuse.
• Any other condition that would render patient unsuitable for study.
• Patients with the following prior conditions are excluded:
• History of pancreatitis.
• Recent diarrheal illness.
• History of weight loss.
• Acute serious illness within 4 weeks prior to study entry.
• Prior Medication:
• Excluded within 4 weeks prior to study entry:
• Erythropoietin.
• Any agent with anti-CMV activity.
• Other investigational agents.
• Prior Treatment:
• Excluded within 4 weeks prior to study entry:
• Surgery.
• Blood transfusion. Drug abuse.

Where it is running

• Mount Zion Med Ctr / UCSF — San Francisco, California, United States
• San Francisco Veterans Adm Med Cntr — San Francisco, California, United States
• Univ of Minnesota — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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