A Study of Ro 24-7429 in Patients With HIV-Related Kaposi's Sarcoma

Completed · Phase 2

Conditions studied: Sarcoma, Kaposi, HIV Infections

In brief

To study the effects of Ro 24-7429 on tumor growth in patients with HIV-related Kaposi's sarcoma. To study the safety and tolerance, effects on HIV replication, and immunologic effects of Ro 24-7429 in this patient population. To explore relationships between exposure to Ro 24-7429 and its metabolites with its antitumor and antiviral activities and drug toxicity.

Key facts

Study ID

NCT00002314

Run by

Hoffmann-La Roche

Last updated by the study team

2005-06-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must have:
• HIV seropositivity.
• Biopsy-proven mucocutaneous Kaposi's sarcoma with fewer than 50 skin lesions and measurable disease.
• No active opportunistic infection. NOTE:
• Patients with CD4 count >= 200 cells/mm3 must have no prior opportunistic infection, as well as no active opportunistic infection.
• Life expectancy of at least 24 weeks.
• Stable weight (+/- 2 kg) by 28 days prior to study entry.

You may not qualify if…

• Co-existing Condition:
• Patients with the following symptoms or conditions are excluded:
• Other active malignancies (except basal cell carcinoma of the skin and in situ cervical cancer).
• Known or suspected hypersensitivity to benzodiazepines.
• Evidence of clinically significant cardiac, respiratory, hepatic, gastrointestinal, endocrine, hematologic, psychiatric, neurologic, dermatologic, or allergic disease as determined by the investigator.
• Ongoing diarrhea (> two liquid stools per day).
• Grade 2 or worse signs and symptoms of AIDS Dementia Complex.
• Alteration of mental status that may interfere with study compliance.
• Concurrent Medication:
• Excluded:
• AZT, ddI, or ddC.
• Experimental antiretrovirals.
• Biologic response modifiers or immunomodulating agents (e.g., interferon).
• Colony stimulating factors (erythropoietin, GM-CSF, G-CSF).
• Ganciclovir.
• Foscarnet.
• H-2 antagonists (cimetidine, ranitidine, famotidine, nizatidine).
• Omeprazole.
• Benzodiazepines.
• Any other investigational compound.
• Ongoing systemic treatment with corticosteroids (other than replacement therapy for adrenal insufficiency or short-term therapy of no more than 28 days for bronchial asthma).
• Cytotoxic chemotherapy (systemic and local).
• Drugs known to cause systemic toxicity, if avoidable (e.g., myelosuppressive, hepatotoxic, nephrotoxic, or neurotoxic drugs).
• Paromomycin sulfate.
• Chronic suppressive therapy for CMV and/or MAI.

Where it is running

• CARE Ctr / UCLA Med Ctr — Los Angeles, California, United States
• New England Deaconess Hosp — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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