The Effects of AZT and Ibuprofen on HIV-Infected Patients With Hemophilia

Completed · Not applicable

Conditions studied: HIV Infections, Hemophilia A

In brief

To determine if platelet dysfunction and/or pharmacologic drug interaction occurs in patients taking both AZT and ibuprofen, which might account for enhanced bleeding tendency.

Key facts

Study ID

NCT00002276

Run by

University of Pittsburgh

Last updated by the study team

2005-06-24

Who can join

Age: 12 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must have:
• Hemophilia.
• HIV-seropositivity confirmed by Western Blot.
• Prior Medication:
• Required:
• AZT for study patients.
• Allowed:
• Ibuprofen.

You may not qualify if…

• Co-existing Condition:
• Patients with the following symptoms and conditions are excluded:
• Hospitalization for opportunistic infection, bacterial infection or malignancy.
• Concurrent Medication:
• Excluded:
• AZT (for control group).
• Antibiotics or other medication for opportunistic infection, bacterial infection, or malignancy.
• Patients with the following prior conditions are excluded:
• Hospitalization for opportunistic infection, bacterial infection, or malignancy.
• Required:
• Ibuprofen.
• AZT 1-2 gm daily (for study patient) or not taking AZT (for control).

Where it is running

• Hemophilia Ctr of Western PA / Univ of Pittsburgh — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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