Evaluation of the Epidermal Langerhans Cell Population in AIDS / ARC Patients by the Topical Application of a Potent Contact Allergen (1-Chloro-2,4-Dinitro-Chlorobenzene) (DNCB)
Completed · Not applicable
Conditions studied: HIV Infections
In brief
To evaluate the effect of application of Dinitrochlorobenzene (DNCB) on the number, morphology, and antigen expression of epidermal Langerhans cells in AIDS and AIDS related complex (ARC) patients.
Key facts
- Study ID
- NCT00002031
- Run by
- University of California, San Francisco
- Last updated by the study team
- 2005-06-24
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients must have the following:
- Stage III or IV HIV infection.
- Provide informed consent.
You may not qualify if…
- Co-existing Condition:
- Patients with the following conditions or symptoms are excluded:
- Kaposi's sarcoma lesions in the proposed treatment sites.
- Liable to require radiation or chemotherapy during the course of the study.
- Not likely to survive the length of the study.
- Obvious ultra-violet-irradiated skin damage in the treatment areas and anyone with recent UV exposure or likely to have such exposure (e.g.:
- holiday tans obtained in Hawaii, members of UV box tanning salons, etc.) Allergy to lidocaine.
- Concurrent Medication:
- Excluded:
- Other Immunomodulators.
- Concurrent Treatment:
- Excluded:
- Radiation.
- Patients with the following are excluded:
- Kaposi's sarcoma lesions in the proposed treatment sites.
- Liable to require radiation or chemotherapy during the course of the study.
- Not likely to survive the length of the study.
- Obvious ultra-violet-irradiated skin damage in the treatment areas.
- Allergy to lidocaine.
- Prior Medication:
- Excluded:
- Prior DNCB therapy.
Where it is running
- San Francisco AIDS Clinic / San Francisco Gen Hosp — San Francisco, California, United States
Full record on ClinicalTrials.gov
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