The Therakos UVAR Photopheresis System in the Treatment of AIDS-Related Complex

Completed · Not applicable

Conditions studied: HIV Infections

In brief

To determine the safety and patient tolerance of UVAR Photopheresis System (extracorporeal photopheresis) in the Treatment of AIDS-Related Complex (ARC).

Key facts

Study ID

NCT00002011

Run by

Therakos

Last updated by the study team

2005-06-24

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must have the following:
• Diagnosis of AIDS-related complex (ARC).
• Veins that can provide adequate access.
• Negative drug screen for drugs of abuse and zidovudine (AZT).
• Be willing to adhere to the protocol and sign a patient informed consent prior to study entry.
• Live within adequate commuting distance to the treatment center.
• Not be on any other investigational drug/device.
• Be 18 - 80 years old but minimum age requirements may be affected by state regulations or specific medical conditions.

You may not qualify if…

• Co-existing Condition:
• Patients with the following conditions or symptoms are excluded:
• Inability to tolerate extracorporeal volume loss during the leukocyte-enrichment phase.
• Photosensitive disease, such as porphyria or systemic lupus erythematosus. Care must be taken in selecting patients who require drugs (either systemically or topically) during the course of the study with photosensitizing potential such as phenothiazines, tetracyclines, sulfonamides or chlorothiazide.
• Renal insufficiency with creatinine > 3 mg/dl.
• Symptoms of toxic effects (World Health Organization Criteria) resulting from previous therapy.
• Severe emotional, behavioral or psychiatric problems that in the opinion of the investigator would result in poor compliance with the treatment regimen.
• Idiosyncratic or hypersensitivity reactions to 8-MOP compounds.
• History of or active Pneumocystis carinii pneumonia, other opportunistic infection or neoplasms (Kaposi's sarcoma), or wasting syndrome.
• Active hepatitis.
• Aphakia because of the significantly increased risk of retinal damage due to absence of lenses.
• Concurrent Medication:
• Excluded:
• Zidovudine (AZT).
• Photosensitizing drugs should not be administered prior to photopheresis treatment.
• Other investigational drugs.
• Concurrent Treatment:
• Excluded:
• Other treatment using an investigational device.
• Patients with the following are excluded:
• Inability to tolerate extracorporeal volume loss during the leukocyte-enrichment phase.
• Photosensitive disease.
• Symptoms of toxic effects (World Health Organization Criteria) resulting from previous therapy.
• Severe emotional, behavioral or psychiatric problems that in the opinion of the investigator would result in poor compliance with the treatment regimen.
• Idiosyncratic or hypersensitivity reactions to 8-MOP compounds.

Where it is running

• Morristown Memorial Hosp — Morristown, New Jersey, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.