Study of Abnormal Blood Clotting in Children With Stroke
Completed
Conditions studied: Abnormalities, Blood Coagulation Disorder, Brain Disease, Cerebrovascular Accident, Vascular Disease
In brief
Effective treatment and prevention strategies for childhood stroke and porencephaly can only be developed once the causes are understood. There is increasing evidence that inherited and acquired coagulation abnormalities alone or in combination with environmental factors, predispose to arterial and venous thrombosis. Inherited abnormalities of factor V Leiden, prothrombin, protein C, protein S, and antithrombin III may account for many of these thromboses. At present there is little information on the existing distribution of these coagulation anomalies in children with thrombosis. Recent reports also suggest that these clotting abnormalities may be responsible for some instances of intracranial hemorrhage, porencephaly, cerebral palsy and fetal death. This study will measure the frequency of several coagulation factor abnormalities (factor V Leiden, prothrombin 20210A, protein C, protein S, antithrombin III, and antiphospholipid antibodies) in children with a history of porencephaly and stroke, and will compare these to the prevalence of these mutations in population controls and family members. We will also describe the exogenous conditions which in concert with these coagulation factors, may have led to the development of thrombosis in these children....
Key facts
- Study ID
- NCT00001927
- Run by
- National Institute of Neurological Disorders and Stroke (NINDS)
- People needed
- 130
- Starts
- 1999-02-22
- Expected to finish
- 2011-05-04
- Last updated by the study team
- 2017-07-02
Who can join
Age: any, up to 45. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- CHILDREN WITH A HISTORY OF PORENCEPHALY OR STROKE:
- Children greater than 18 years of age.
- Maternal history of cocaine abuse during pregnancy.
- History of cancer.
- History of other chromosomal or metabolic disorder.
- History of trauma and or child abuse.
- Isolated subdural hematomas.
- History of aneurysm or vascular malformations.
- Congenital heart disease.
- Sickle cell disease.
- History of CNS infection.
- HEALTHY CHILDREN:
- Children greater than 18 years of age.
- Maternal history of cocaine abuse during pregnancy.
- History of cancer.
- History of other chromosomal or metabolic disorder.
- History of trauma and or child abuse.
- Isolated subdural hematomas.
- History of aneurysm or vascular malformations.
- Congenital heart disease.
- Sickle cell disease.
- History of CNS infection.
- History of stroke or porencephaly.
- HEALTHY MOTHERS:
- Volunteer has biological children without a history of cancer, head trauma, aneurysm, chromosomal or metabolic disorder, congenital heart disease, sickle cell disease, meningitis or encephalitis, or stroke.
Where it is running
- National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.