The Impact of Familiarity and Emotional Attachment on the Visual Processing of Faces
Completed
Conditions studied: Bereavement, Healthy
In brief
This study uses functional magnetic resonance imaging (fMRI) to look at brain activity while patients view pictures of people's faces that they are familiar with or have emotional attachment to. The functional MRI (fMRI) procedure allows researchers to "see the brain at work." It uses the same powerful magnetic fields and weak electromagnetic radiation (radiowaves) as standard structural MRI. However, functional MRI can also show areas of increased blood flow, which relates to increased activity by brain cells. This research study builds on previous studies that identified specific areas of the brain that are activated by visual stimuli showing faces. However, previous research used anonymous faces as stimuli. This study will use faces of individuals known to the patient. There are three experiments that will be conducted in the study; 1. Experiment 1 will attempt to determine the effects of familiarity of the photographed face on brain activity patterns. Patients will view familiar faces, the faces of close friends and relatives, and the faces of famous people. 2. Experiment 2 will look at how maternal attachment affects the response to visual stimuli. Mothers will view pictures of their first born child, as well as those of familiar children to whom they are not related, unfamiliar children, and unfamiliar adults. 3. Experiment 3 will explore the effects of interpersonal attachment and loss on response to visual stimuli. In this experiment, bereaved spouses will view pictures of their deceased spouse, those of living family members, and those of unfamiliar people.
Key facts
- Study ID
- NCT00001913
- Run by
- National Institute of Mental Health (NIMH)
- People needed
- 80
- Starts
- 1998-10-01
- Expected to finish
- 2003-10-01
- Last updated by the study team
- 2008-03-04
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Subjects will be recruited through advertisements within Bethesda and surrounding communities.
- All subjects must be right-handed.
- For experiments #1 and 2, subjects will be 20-40 years old.
- For study #3, subjects will be 45-75 years old.
- For experiment #2, all subjects will be mothers with a non-adopted child aged 6-12 years old.
- For experiment #3, subjects in the bereaved group will have become spousally bereaved within the past 6 months.
You may not qualify if…
- Subjects will be excluded if they have a history of significant medical disorders (including learning disabilities, seizures, history of head trauma, hypertension, or cerebrovascular disease) or psychiatric disorders, including substance abuse. (An exception to this is that bereaved subjects in experiment #3 will not be excluded if they meet DSM-IV criteria for major depressive disorder (non-psychotic), adjustment disorder with depressed mood, or bereavement, as long as their current Hamilton-D score is less than 13).
- Subjects will also be excluded if they take any prescribed medications (including birth control pills), if they are pregnant, or if their vision is inadequate to see the visual stimulus.
- In addition, subjects in experiment #2 will receive a DICA-P (Diagnostic Interview for Children and Adolescents, Parent Version), and will be excluded if their child meets diagnostic criteria for a psychiatric illness.
Where it is running
- National Institute of Mental Health (NIMH) — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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