Microarray Analysis for Human Genetic Disease
Completed
Conditions studied: Breast Neoplasm, Hereditary Neoplastic Syndrome, Melanoma, Ovarian Neoplasm
In brief
This study will look at genetic changes which occur in the development of male and female breast cancer and other cancer. It will use a new technology called DNA microarray hybridization that looks at a wide array of genes to identify disease-associated patterns in the human genome (complete set of human genes). Numerous studies have linked particular genes to a given disease, but there is very little information on patterns of gene expression (production of proteins from genetic coding) in the entire human genome. Pinpointing genetic abnormalities in disease may help classify different forms of cancer and perhaps lead to new avenues of treatment or prevention. A primary goal of this study will be to create a database of gene expression for human cancers and other disorders that will provide the basis for finding genetic abnormalities in disease. Tumors specimens used in this study will be taken from tissues biopsied from patients with breast, colon cancer, sarcomas or melanoma as part of their routine care. Patients in the study will be among those receiving care at the: Department of Oncology, University Hospital, University of Lund, Sweden (breast cancer); Department of Medicine, University of Michigan, Ann Arbor, Michigan (breast cancer); Surgery Branch, National Cancer Institute, Bethesda, Maryland (melanoma), Johns Hopkins Univ. (colon cancer), Memorial Sloan Kettering (sarcoma). Patients in the study will have a family history taken and will complete a questionnaire. Some patients will be asked to have a blood test. Breast cancer patients will have a mammogram if one has not been done within the last year.
Key facts
- Study ID
- NCT00001898
- Run by
- National Human Genome Research Institute (NHGRI)
- People needed
- 1500
- Starts
- 1999-06-29
- Expected to finish
- 2008-05-20
- Last updated by the study team
- 2017-07-02
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Arizona Cancer Center — Tucson, Arizona, United States
- Johns Hopkins University — Baltimore, Maryland, United States
- University of Michigan — Ann Arbor, Michigan, United States
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- MD Anderson Cancer Center — Houston, Texas, United States
- Helsinki University Central Hospital — Helsinki, Finland
- University of Iceland — Reykjavik, Iceland
- University of Lund — Lund, Sweden
Full record on ClinicalTrials.gov
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