Identification of Genes Associated With Lung Disease in Patients With Rheumatoid Arthritis

Completed

Conditions studied: Healthy, Pulmonary Fibrosis, Rheumatoid Arthritis

In brief

Pulmonary fibrosis (PF) is a condition in which the lungs of a patient become scarred and fibrous. It has been known to occur in as many as 40% of patients diagnosed with rheumatoid arthritis (RA). The cause of the pulmonary fibrosis in patients with RA is unknown. Data gathered from previous research studies suggest that genetics may play a role in the development of PF in patients with rheumatoid arthritis. However, the actual genetic factors involved in the disease process have not been identified. The goal of this study is to identify the genetic markers in patients with pulmonary fibrosis and rheumatoid arthritis.

Key facts

Study ID

NCT00001885

Run by

National Heart, Lung, and Blood Institute (NHLBI)

People needed

400

Starts

1999-03-21

Expected to finish

2007-12-28

Last updated by the study team

2017-07-02

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Individuals with any of the following:
• Inhalational exposure to fibrogenic fibers or dusts (e.g., asbestos, silica, coal, beryllium).
• Chronic pulmonary disorders other than pulmonary fibrosis.
• Other collagen vascular disorders (e.g., systemic lupus erythematosus, scleroderma, polymyositis, mixed connective tissue disease).
• Non-rheumatoid arthritis.
• Viral infections associated with PF (e.g., hepatitis B, hepatitis C, human immunodeficiency virus).
• Pregnancy.

Where it is running

• National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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