Specimen Collection for Individuals With Lung Disease Associated With Rheumatoid Arthritis

Completed

Conditions studied: Pulmonary Fibrosis, Rheumatoid Arthritis

In brief

Pulmonary fibrosis (PF) is a condition in which the lungs of a patient become scarred and fibrous. It has been known to occur in as many as 40% of patients diagnosed with rheumatoid arthritis (RA). The cause of the pulmonary fibrosis in patients with RA is unknown. Researchers hope to improve their understanding of the disease process involved in PF and RA by analyzing specimens collected by bronchoscopy, lung biopsy, lung transplantation, or autopsy from patients with these conditions. The purpose of this study is to collect specimens from rheumatoid arthritis patients with and without pulmonary fibrosis as well as patients with pulmonary fibrosis without associated diseases or cause (idiopathic pulmonary fibrosis).

Key facts

Study ID: NCT00001884
Run by: National Heart, Lung, and Blood Institute (NHLBI)
Starts: 1999-03-21
Expected to finish: 2007-12-28
Last updated by the study team: 2017-07-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

Individuals with any of the following:
Forced expiratory volume in one second (FEV(1)) less than 1L.
Inhalational exposure to fibrogenic fibers or dusts (i.e., asbestos, silica, coal, beryllium).
Chronic cardiopulmonary disorders other than pulmonary fibrosis.
Other collagen vascular disorders (i.e., systemic lupus erythematosus, scleroderma, polymyositis, mixed connective tissue disease).
Non-rheumatoid arthritis.
Viral infections associated with PF (i.e., hepatitis B, hepatitis C, human immunodeficiency virus).
Uncorrectable bleeding diathesis.
Pregnancy or lactation.

Where it is running

Boston University — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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