(1)H-Nuclear Magnetic Resonance Spectroscopic Imaging of the Brain in Patients Who Receive Neurotoxic Therapy
Completed
Conditions studied: Brain Cancer, Brain Neoplasms
In brief
Central nervous system toxicity is a recognized side effect of certain therapies for cancers, particularly cranial irradiation, intrathecal therapy or systemic high-dose chemotherapy. The pathophysiologic mechanisms and clinical manifestations vary. Previous studies defining MRI changes and correlating these with neurocognitive deficiencies have been inconsistent. Recent advances in brain imaging may help to better define neurotoxic effects. (1)H-NMRS is a noninvasive method of obtaining in vivo biochemical information from the brain. It has been used to study patients with CNS disorders, including neuronal disorders. In this study, (1)H-NMRS will be used to objectively characterize CNS toxicities in patients with cancer who are receiving potentially neurotoxic therapies. In addition, we will retrospectively evaluate patients with known or suspected neurotoxicity associated with cancer therapy, to determine if changes in spectroscopic patterns are associated with CNS toxicity.
Key facts
- Study ID
- NCT00001807
- Run by
- National Cancer Institute (NCI)
- People needed
- 50
- Starts
- 1999-04-16
- Expected to finish
- 2019-04-18
- Last updated by the study team
- 2019-04-24
Who can join
Age: 4 and older, up to 20. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Pregnancy.
- Patients with braces or permanent retainers.
- Patients with pre-existing neurologic or genetic conditions, unrelated to the tumor.
- Patients who are unable (either because of physical or psychological factors) to undergo imaging studies and who are not a candidate for anesthesia.
- Patients who have an absent gag reflex or swallowing difficulties.
- Metallic implants, including cardiac pacemakers, neural pacemakers, shrapnel, cochlear implants or ferrous surgical clips.
- History of severe reaction to Gadolinium.
Where it is running
- National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.