The Role of Emotion in the Development of Psychopathology
Completed
Conditions studied: Mood Disorder
In brief
The dysregulated experience and expression of emotion is implicated in psychiatric disorders associated both with externalizing problems (aggressive, antisocial behaviors) and internalizing problems (anxiety, depression). Adolescence is a critical juncture in the development of these disorders because of the increased incidence and differentiation of clinical problems during this time period. This is a biobehavioral, longitudinal investigation of the role of emotion in the development of psychopathology in adolescence. The focus is on socialization experiences and biological processes that contribute to emotion dysregulation and disorder in male and female youths between 11 and 16 years of age. Groups studied include (1) comorbid externalizers and internalizers, (2) externalizers only, (3) internalizers only, and (4) asymptomatic youth. The adolescents are assessed again two years later, with instruments and paradigms similar to those used at Time 1. One theme pertains to the integration and disconnection of emotions across systems (e.g., physiological and self-report of experience), and how different patterns of emotion relate to psychopathology. A second theme pertains to development changes in how disorders are manifested (e.g., increased differentiation along gender specific pathways). The anticipated number of patient days per year is 240 for adolescents and mothers, and 120 days for fathers.
Key facts
- Study ID
- NCT00001654
- Run by
- National Institute of Mental Health (NIMH)
- People needed
- 1200
- Starts
- 1997-05-01
- Expected to finish
- 2003-05-01
- Last updated by the study team
- 2008-03-04
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Subjects and their families will be recruited from the community.
- Inclusionary criteria will be based on mother and youth report of (a) emotion regulation problems and (b) the presence of subclinical or clinical symptomatology based on broad-band scales of the Youth Self-Report or mother's report of behavior problems.
- Individuals meeting entry criteria will be offered entry into the study, and others will be notified.
You may not qualify if…
- A debilitating physical impairment (e.g., seizure disorder, cerebral palsy, head trauma).
- Significant intellectual impairment (i.e., IQ less than 70).
- History of psychosis.
- Any condition that would impair a participant's ability to respond to the study's paradigms will be excluded from this study at the time of screening.
Where it is running
- National Institute of Mental Health (NIMH) — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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