Study of Blood Flow in Heart Muscle
Completed · Phase 2
Conditions studied: Coronary Disease, Healthy, Hypertrophic Cardiomyopathy, Myocardial Ischemia
In brief
Blood flows to areas of the heart providing oxygen and fuel to the pumping muscle. Occasionally the arteries providing the fuel can become blocked. This occurs in coronary artery disease. Magnetic resonance imaging (MRI) can be used to evaluate the blood flow to different areas of the heart muscle. In this study magnetic resonance imaging will be compared to other diagnostic tests (radionucleotide perfusion studies) capable of measuring blood flow to heart muscle.
Key facts
- Study ID
- NCT00001631
- Run by
- National Heart, Lung, and Blood Institute (NHLBI)
- People needed
- 249
- Starts
- 1997-08-01
- Expected to finish
- 2003-01-01
- Last updated by the study team
- 2008-03-04
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Ages 18 to 80.
- Either sex.
- Capable of giving informed consent.
- Group 1: Outpatients with known or suspected coronary artery disease with clinical indication for radionuclide perfusion imaging.
- Group 2: Patients with non-obstructive hypertrophic cardiomyopathy with clinical indication for radionuclide perfusion imaging.
- Group 3: Normal volunteers.
- Positive stress thallium or stress sestamibi (i.e., exercise, adenosine, dobutamine or dypiridamole) at the NIH.
You may not qualify if…
- Pregnancy.
- Unstable angina.
- Uncontrolled hypertension (SBP greater than 185, DBP greater than 105).
- Recent myocardial infarction (less than 5 days).
- 2nd or 3rd degree heart block by ECG.
- Asthma, emphysema, renal failure, acute medical illness (fever, pneumonia, etc.) or anemia (hct less than 30).
- Cardiac pacemaker or implantable defibrillator, aneurysm clip, neural stimulator, any type of ear implant, metal in your eye, any implanted device (i.e. insulin pump, drug infusion device) or any metallic foreign body, shrapnel, or bullet.
Where it is running
- National Heart, Lung and Blood Institute (NHLBI) — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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