Effect of Insulin on Endothelin-Dependent Vascular Tone in the Forearm Circulation

Completed · Phase 1

Conditions studied: Hyperinsulinemia

In brief

Previous studies have shown that insulin may stimulate the release of endothelin (ET) from endothelial cells. This mechanism may contribute to the adverse vascular effects determined by chronic hyperinsulinemia. The aim of this study will be to evaluate the effect of local hyperinsulinemia on ET activity in the forearm circulation. To this purpose, we will assess the forearm blood flow response to ET receptor antagonism in control conditions and during intraarterial infusion of insulin. We will also measure changes in plasma ET-1 levels in response to the different pharmacological stimuli.

Key facts

Study ID
NCT00001624
Run by
National Heart, Lung, and Blood Institute (NHLBI)
People needed
16
Starts
1997-03-01
Expected to finish
2000-03-01
Last updated by the study team
2008-03-04

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.