Genetic Linkage Studies of Stuttering

Completed

Conditions studied: Stuttering

In brief

Stuttering is an abnormality in speech that affects the rhythm of speech. People who stutter know what they wish to say, but at the time are unable to say it because of involuntary repetition, unnecessary lengthening (prolongation), or early stopping (cessation). Stuttering is characterized by repetitions or prolongation of the first syllable, or silent prolongations, sometimes known as blocks. Researcher intend on studying the genetic basis for stuttering. The goal of the study is to find the genes that help cause stuttering and determine regions of the human genetic make-up (genome) that are linked to stuttering.. To do this researchers will study the patterns of inheritance in families who have had members who stutter. The study has two objectives. The first objective is to develop a large collection of DNA samples from individuals in stuttering families, that will include both members that stutter and who do not stutter. The second objective of the study will be to find out the basic combination of genes (genotype) making up all of the participants DNA. Once this is completed researchers hope to map out and find areas or regions of DNA that are linked to stuttering. Genetic linkage is the initial step in positional cloning, and the cloning of genes which predispose individuals to stuttering is a long term goal of this research study.\<TAB\>

Key facts

Study ID

NCT00001604

Run by

National Institute on Deafness and Other Communication Disorders (NIDCD)

People needed

3044

Starts

2003-07-22

Expected to finish

2019-06-24

Last updated by the study team

2024-11-18

Who can join

Age: 6 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Stuttering only as a young child (before age 5) with no other family members who stutter
• Inability to provide informed consent or have a parent/guardian to provide consent
• Development of stuttering following trauma to the central nervous system.
• Chronic medical conditions that prevent informed consent or clear evaluation of stuttering, including stroke, dementia, and degenerative neurological disease.
• Inability to travel to the NIH Clinical Center for Phase 2

Where it is running

• National Institutes of Health Clinical Center — Bethesda, Maryland, United States
• National Rehabilitation Center for Persons with Disabilities Hospital — Saitama, Japan
• NCEMB - University of Punjab — Lahore, Pakistan

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.