Genetic Factors Related to Stuttering
Completed
Conditions studied: Stuttering
In brief
Stuttering is an abnormality in speech that affects the rhythm of speech. People who stutter know what they wish to say, but at the time are unable to say it because of involuntary repetition, unnecessary lengthening (prolongation), or early stopping (cessation). This study is designed to increase understanding of the genetic factors that may relate to stuttering. Deoxyribonucleic acid (DNA) is a protein found in the nucleus of all cells. It is responsible for carrying the genetic information of the organism. DNA provides the directions for making all of the substances in the human body. DNA can be linked together in small segments called genes. Genes can contain information about anything related to an organism. In order for researchers to determine what genes are directly related to stuttering they must conduct several types of studies. Linkage studies, are studies of families that have a lot of members who stutter from several generations. The linkage studies will be completed using adult individuals who are diagnosed as persons who stutter and persons who have never stuttered, from one or more families with large numbers of family members who have stuttered over several generations. Candidate gene studies, look closely at genes suspected to be related to stuttering in patients who may or may not have a significant family history of stuttering. By conducting these studies, researchers hope to learn more about genes related to stuttering and ultimately find out what causes stuttering.
Key facts
- Study ID
- NCT00001602
- Run by
- National Institute on Deafness and Other Communication Disorders (NIDCD)
- People needed
- 500
- Starts
- 1996-10-01
- Expected to finish
- 2005-02-01
- Last updated by the study team
- 2008-03-04
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects must be over the age of 5 and under the age of 90.
- Subjects must be in general good health, without evidence of chronic medical illness.
- Onset of stuttering in affected individuals must have occurred in childhood (between 3 and 10 years of age), unrelated to psychological or neurological trauma.
- Subjects will not be tested for the presence of HIV antibodies. Persons with positive HIV antibodies will not be excluded, unless they are taking medication which may change their performance on tasks used for phenotypic assignment.
- Subjects will be screened for history of psychiatric illness, such as depression, anxiety or obsessive-compulsive disorders according to DSM-IV criteria. A history of these disorders will not disqualify any subject from participation, but will be noted as a variable in phenotypic assignment.
Where it is running
- National Institute on Deafness and Other Communication Disorders (NIDCD) — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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