Characteristics of Idiopathic Familial Voice Disorders
Completed
Conditions studied: Laryngeal Disease, Spastic Dysphonia, Voice Disorder
In brief
The purpose the study is to determine the genetic causes of specific voice disorders that run in families. Researchers are particularly interested in two conditions; 1. Spasmodic dysphonia 2. Vocal fold paralysis Familial vocal fold paralysis can be a life-threatening disorder that can cause difficulty with vocal fold movement for breathing and voice and sometimes for swallowing. Studies are ongoing at the NIH to better understand the pathophysiology and to relate it to the genetic pattern of inheritance. Families are being recruited to participate in these studies and are being provided with further information on the disorder and genetic counseling if desired. Physician referral is requested for affected members of families with vocal fold paralysis of an unknown cause occurring over at least 2 generations. All travel, lodging, examination and counseling costs are covered for both affected and unaffected members of a family. Examinations include: voice, laryngeal, neurological, electrodiagnostic testing, genetic counseling, and radiological studies....
Key facts
- Study ID
- NCT00001552
- Run by
- National Institute of Neurological Disorders and Stroke (NINDS)
- People needed
- 270
- Starts
- 1996-05-22
- Last updated by the study team
- 2017-07-02
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Any patient with a history of airway obstruction will be excluded from the study.
- Structural abnormalities affecting the larynx such as vocal fold nodules, polyps, carcinoma, cysts, contact ulcers, or inflammation (laryngitis).
- Reduction in vocal fold movement range during non-speech tasks such as whistling which would suggest either paralysis or paresis, joint abnormality or neoplasm.
- No smokers or tobacco users will be included in the study.
- Subjects with history of a psychiatric disorder, under the care of a psychiatrist, or on medications for treatment of a psychiatric disorder will be excluded from the study. Examples of psychiatric disorders to be excluded are: somatoform disorders, conversion disorders, currently under treatment for a major depression, or a history of schizophrenia or a bipolar disorder. However, a history of a previous episode of a minor reactive depression would not exclude a person from participation.
Where it is running
- University of Iowa — Iowa City, Iowa, United States
- National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
- Kennedy-Galton Centre Medical & Community Genetics — Harrow, United Kingdom
- Institute of Cancer Research — Sutton, United Kingdom
Full record on ClinicalTrials.gov
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