Effect of High Levels of Oxygen and Smoking on the Lungs in Human Volunteers
Completed
Conditions studied: Healthy Volunteers
In brief
Patients with lung disease experiencing difficulty breathing can be treated with oxygen therapy. This involves the delivery of "extra" oxygen by a face-mask or through small tubes placed in the nose called nasal prongs. This extra oxygen can have concentrations as high as 100% pure oxygen. The concentration of oxygen in normal air is only 21%. The high concentration of oxygen can help to provide enough oxygen for all of the organs in the body. Unfortunately, breathing 100% oxygen for long periods of time can cause changes in the lungs, which are potentially harmful. Researchers believe that by lowering the concentration of oxygen therapy to 40% patients can receive it for longer periods of time without the risk of side effects. This study is designed to evaluate the effects of oxygen therapy at 100% and 40% for 12 18 hours on the lungs of normal volunteers. Results of this study will help to determine if levels of oxygen therapy currently accepted as being "safe" may actually be damaging to the lungs.
Key facts
- Study ID
- NCT00001464
- Run by
- National Heart, Lung, and Blood Institute (NHLBI)
- People needed
- 77
- Starts
- 1995-08-22
- Expected to finish
- 2007-07-10
- Last updated by the study team
- 2021-08-27
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Any study subject who does not fulfill the criteria for eligibility.
- Individuals with a history of allergy or adverse reactions to atropine or any local anesthetic;
- Individuals testing positive for the human immunodeficiency virus or hepatitis virus;
- Individuals on chronic medications or currently receiving medications;
- Pregnant or lactating individuals, since the effects of hyperoxia on the fetus are unclear.
Where it is running
- National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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