Bone Mineral Density in Women With Major Depression
Completed
Conditions studied: Healthy, Involutional Depression, Osteoporosis
In brief
The purpose of this study is to examine calcium absorption and bone mineral density in women with depression. Research indicates that pre-menopausal women with depression have significantly lower bone mineral density (BMD) than pre-menopausal women without depression. Although the mechanisms of BMD loss are unclear, researchers believe that individuals with depression have impaired calcium absorption. However, it is unknown whether the abnormal absorption is a result of depression or a side effect of the drugs used to treat it. This study will compare calcium absorption in women with depression and in healthy women without depression. Participants in this study will be given two non-radioactive calcium isotopes. One can be taken by mouth and the other must be injected. Participants will have the level of isotopes in their urine measured to estimate true fractional calcium absorption (TFCA). Participants may also have a dual X-ray absorptiometry (DEXA) scan to measure total body adiposity and lean body mass.
Key facts
- Study ID
- NCT00001413
- Run by
- National Institute of Mental Health (NIMH)
- People needed
- 585
- Starts
- 1994-04-06
- Expected to finish
- 2007-01-19
- Last updated by the study team
- 2017-07-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- A history of current or past major depression of at least four months duration, or a history of two or more brief depressive episodes will be the primary criterion for inclusion.
- Patients with Bipolar Disorder will be eligible if they meet the depressive episode criterion.
- No specific inclusion criteria are set for normal volunteers.
You may not qualify if…
- DEPRESSED SUBJECTS:
- Pregnant women will not be eligible to participate.
- Known medical causes of osteoporosis, other than depression.
- Current or past history of eating disorders, or schizophrenia, as per DSM-IV.
- Chronic use of oral or parenteral steroids (daily use for 3 months or longer).
- HEALTHY SUBJECTS:
- Pregnant women will not be eligible to participate.
- Known medical causes of osteoporosis.
- Any history of DSM-IV diagnosis, including depression, eating disorders, and alcohol or drug abuse.
- History or current evidence of any significant clinical or laboratory abnormalities.
Where it is running
- National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.