Salivary Evaluation in Healthy Volunteers

Completed

Conditions studied: Healthy, Salivary Gland Disease

In brief

Saliva is critical in maintaining oral health and comfort. Our laboratory has investigated several disorders of salivary glands. The purpose of this protocol is to obtain data from healthy volunteers for comparison with data from patients with salivary dysfunction. We plan to utilize the NIH Clinical Center Clinical Research Volunteer Program to solicit paid participation from healthy adults. Study procedures are accomplished in 2-3 outpatient visits that include an interview, saliva collection, lip biopsy, clinical laboratory studies, dry eye examination, and lip biopsy follow up, as needed. These are routine diagnostic procedures. Biopsy specimens may be used in clinical and laboratory studies, such as in vitro biochemical analysis or in vivo transplantation. Some of the Healthy Volunteers may be asked to participate in an MRI study of the salivary glands.

Key facts

Study ID

NCT00001390

Run by

National Institute of Dental and Craniofacial Research (NIDCR)

People needed

173

Starts

1993-10-26

Expected to finish

2018-09-20

Last updated by the study team

2018-09-24

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Known pregnancy.
• Chronic medical illness, other than well-controlled hypertension or hyperlipidemia.
• Chronic use of medications, with the exception of oral contraceptives, hormone replacement therapy, antihypertensives and antilipemics.
• Have problems with dry mouth and/or dry eyes.
• NIH employees who are subordinates/relatives/co-workers of investigators.

Where it is running

• National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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