Metabolic Abnormalities in Children With Epilepsy
Completed
Conditions studied: Generalized Epilepsy, Infantile Spasms, Metabolic Disease, Partial Epilepsy, Seizures
In brief
This study is designed to use positron emission tomography to measure brain energy use. Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal processes of the brain (central nervous system) of normal individuals and patients with neurologic illnesses without physical / structural damage to the brain. When a region of the brain is active, it uses more fuel in the form of oxygen and sugar (glucose). As the brain uses more fuel it produces more waste products, carbon dioxide and water. Blood carries fuel to the brain and waste products away from the brain. As brain activity increases blood flow to and from the area of activity increases also. Researchers can label a sugar with a small radioactive molecule called FDG (fluorodeoxyglucose). As areas of the brain use more sugar the PET scan will detect the FDG and show the areas of the brain that are active. By using this technique researchers hope to answer the following questions; 4\. Are changes in brain energy use (metabolism) present early in the course of epilepsy 5\. Do changes in brain metabolism match the severity of patient's seizures 6\. Do changes in metabolism occur over time or in response to drug therapy
Key facts
- Study ID
- NCT00001325
- Run by
- National Institute of Neurological Disorders and Stroke (NINDS)
- People needed
- 80
- Starts
- 1992-04-01
- Expected to finish
- 2004-06-01
- Last updated by the study team
- 2008-03-04
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with partial seizures, infantile spasms and Lennox-Gastaut syndrome will be selected.
You may not qualify if…
- Evidence of a structural lesion as cause for epilepsy.
- Degenerative or metabolic disease.
- Inability to comply with the protocol.
Where it is running
- National Institute of Neurological Disorders and Stroke (NINDS) — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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