Magnetic Resonance Imaging (MRI) of Neuropsychiatric Patients and Healthy Volunteers

Completed

Conditions studied: Genotype, Allelic Frequencies of Genetic Markers, Brain Mapping, Brain Disease, fMRI

In brief

The purpose of this study is to use brain imaging technology to compare differences in brain structure, chemistry, and functioning in individuals with brain and mental disorders compared to healthy volunteers. Schizophrenia is a brain disorder that results from subtle changes and abnormalities in neurons. These deficits likely occur in localized regions of the brain and may result in widespread, devastating consequences. The neuronal abnormalities are inherited through a complex combination of genetic and environmental factors. Brain imaging technologies can be used to better characterize brain changes in individuals with schizophrenia. This study will use magnetic resonance imaging (MRI) scans to identify predictable, quantifiable abnormalities in neurophysiology, neurochemistry and neuroanatomy that characterize schizophrenia and other neurological and neuropsychiatric disorders....

Key facts

Study ID

NCT00001284

Run by

National Institute of Mental Health (NIMH)

People needed

2802

Starts

1991-05-10

Expected to finish

2019-02-25

Last updated by the study team

2019-12-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• CONTROLS AND PATIENTS:
• Impaired hearing.
• Pregnancy.
• Head trauma with loss of consciousness in the last year, or any evidence of functional impairment due to and persisting after head trauma.
• Patients or healthy volunteers with a known risk from exposure to high magnetic fields (e.g. patients with pace makers) and those who have metallic implants (e.g. braces) in the head region (likely to create artifact on the MRI scans) will be excluded from participating in the fMRI studies.
• Patients:
• Coexistence of another major mental illness at the time of the study. If the patients experienced other mental illnesses in the past (e.g. major depression), then this should be judged to be fully recovered.
• Criteria for substance abuse met in the last 6 months.
• Criteria for substance dependence in the last year. If criteria for dependence were met in the past, then the duration of the disorder was less than 3 years, or not judged to have produced long-term brain changes to allow the patient to be in the study.
• Major concurrent medical illness likely to interfere with the acquisition of the task.
• Concomitant medications which could interfere with performance on the task.
• Presence of dyskinetic movements of the face and tongue (likely to interfere with eyeblink measures, or of gross involuntary movements of the whole body (likely to interfere with positioning in the MRI scanner).

Where it is running

• National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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