Ovarian Follicle Function in Patients With Primary Ovarian Failure

Completed

Conditions studied: Amenorrhea, Hypoaldosteronism, Hypogonadism, Infertility, Premature Ovarian Failure

In brief

No proven therapy to restore ovarian function and fertility is available to patients with karyotypically normal spontaneous premature ovarian failure. We know that one-half of these patients have primordial follicles remaining in the ovary, and these follicles can function intermittently. This is a diagnostic omnibus protocol that permits baseline clinical evaluation of patients with prematurem ovarian failure. The findings will determine patients' suitability for specifically focused therapeutic research protocols.

Key facts

Study ID

NCT00001275

Run by

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

People needed

1134

Starts

1991-05-12

Expected to finish

2017-02-08

Last updated by the study team

2017-10-06

Who can join

Age: 18 and older, up to 42. Sex: female. Healthy volunteers: not accepted.

You may not qualify if…

• Women with evidence for karyotypic, metabolic, toxic, or iatrogenic cause of the ovarian insufficiency were not candidates.

Where it is running

• National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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