The Effects of Estrogen on Cognition in Girls With Turner Syndrome
Completed · Phase 2
Conditions studied: Gonadal Dysgenesis, Turner's Syndrome
In brief
The development of the brain in females is a result of a combination of factors. During puberty estrogen plays a role in influencing brain development. Cultural and environmental factors also play a role in the development of the brain. Female patients with Turner syndrome lack the ability to produce estrogen due to undeveloped ovaries. Therefore, Turner syndrome is the perfect condition to study how estrogen (or the lack of estrogen) influences a person's behavior and thinking. This study will compare cognitive differences (visual motor skills, visual-spatial, psychosocial behavior, and visual memory) of patients with Turner syndrome to normal patient controls. Researchers will use the Weschler Intelligence Scale for Children-Revised (WISC-R) along with other tests and scales to measure different aspects of the patient's cognitive ability. In addition the study will review patients with Turner syndrome who previously received estrogen replacement as infants and children in a related research study. Researchers hope to demonstrate that estrogen replacement will improve cognition and behavior in girls with Turner syndrome.
Key facts
- Study ID
- NCT00001253
- Run by
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- People needed
- 950
- Starts
- 1990-05-01
- Expected to finish
- 2004-03-01
- Last updated by the study team
- 2008-03-04
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Patients will include girls and women ages 5-50 yr with the diagnosis of Turner syndrome based on absence of all or part of one of the X chromosomes.
- Control subjects must be within +/- 2SD for height and weight and have normal intelligence and educational achievement.
- Biological parents (both male and female) of TS subjects may be included in this study, but only to have blood drawn for genetic testing in order to determine the origin of the X-chromosome of their daughters.
You may not qualify if…
- Those with severe physical or neurocognitive impairment, preventing accurate completion of the cognitive tasks, will be excluded.
- Normal subjects who have qualified for or participated in gifted and talented or remedial education programs.
Where it is running
- National Institute of Child Health and Human Development (NICHD) — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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