Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers

Running, not enrolling

Conditions studied: Attention Deficit Hyperactivity Disorder, Schizophrenia, Attention Deficit Disorder With Hyperactivity

In brief

Magnetic Resonance Imaging (MRI) unlike X-rays and CT-scans does not use radiation to create a picture. MRI use as the name implies, magnetism to create pictures with excellent anatomical resolution. Functional MRIs are diagnostic tests that allow doctors to not only view anatomy, but physiology and function. It is for these reasons that MRIs are excellent methods for studying the brain. In this study, researchers will use MRI to assess brain anatomy and function in X and Y chromosome variation, healthy volunteers, and patients with a variety of childhood onset psychiatric disorders. The disorders include attention deficit disorder, autism, congenital adrenal hyperplasia, childhood-onset schizophrenia, dyslexia, obsessive compulsive disorder, Sydenham's chorea, and Tourette's syndrome. Results of the MRIs showing the anatomy of the brain and brain function will be compared across age, sex (gender), and diagnostic groups. Correlations between brain and behavioral measures will be examined for normal and clinical populations.

Key facts

Study ID

NCT00001246

Run by

National Institute of Mental Health (NIMH)

People needed

4274

Starts

1990-06-19

Last updated by the study team

2026-08-07

Who can join

Age: 3 and older, up to 120. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• NIMH staff and their immediate family are excluded from participation.
• Exclusion criteria for healthy controls:
• Presence of severe psychiatric disorder (as diagnosed prior to participant study enrollment) in the participant. For these purposes, exclusionary severe psychiatric disorder includes schizophrenia and bipolar affective disorder.
• Presence or history of medical conditions known to affect cerebral anatomy.
• Dental braces.
• Contraindications for MRI scanning according to the NMR Center MRI Safety Screening Questionnaire and guidelines.
• For females who have reached menarche: Pregnancy or inability or unwillingness to undergo pregnancy testing.
• Exclusion criteria for all affected participant populations, including parents and siblings of the affected participants:
• Dental braces.
• Contraindications for MRI scanning according to the NMR Center MRI Safety Screening Questionnaire and guidelines.
• For females who have reached menarche: Pregnancy or inability or unwillingness to undergo pregnancy testing.
• Evidence of another medical condition or traumatic event known to affect cerebral anatomy.
• A known genetic disorder (other than the condition under investigation) that would be expected to significantly impact findings from cognitive testing and/or neuroimaging.

Where it is running

• National Institutes of Health Clinical Center — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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