The Effect of GnRH on Pitutitary Hormones in Menstrual-Cycle Mood Related Disorders

Completed

Conditions studied: Depressive Disorder, Healthy, Mental Disorders, Mood Disorders

In brief

The normal menstrual cycle is produced by a series of hormonal signals that starts with the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus. The hypothalamus is located in the brain and is often referred to as the master gland. GnRH then acts on the pituitary gland and causes it to release two hormones, follicle stimulating hormone (FSH) and lutenizng hormone (LH). LH and FSH act on the ovary and cause it to release the hormones directly involved in menstruation, estrogen and progesterone. The purpose of this research study is to evaluate the hypothalamic-pituitary-gonadal axis activity as measured by pituitary hormones, FSH and LH in response to intravenous doses of gonadotropin releasing hormone (GnRH) in menstrual cycle-related hormones.

Key facts

Study ID
NCT00001232
Run by
National Institute of Mental Health (NIMH)
People needed
140
Starts
1988-07-01
Expected to finish
2000-06-01
Last updated by the study team
2008-03-04

Who can join

Age: any. Sex: female. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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