Botulinum Toxin for the Treatment of Involuntary Movement Disorders
Recruiting now
Conditions studied: Movement Disorders
In brief
BTX has been used since the 1980s in support of the research mission of NINDS. Initial studies were focused on expanding the applicability of BTX treatment to movement disorders and exploring new indications. We evaluated the efficacy of an alternative serotype, type F. Under other protocols, we continue to study the physiology of movement disorders and BTX response. The application of BTX therapy to movement disorders requires an understanding of BTX preparation and handling. The treatment must be tailored to the disorder under treatment and to its expression in the individual patient. Users must know the specific techniques of injection, including the use of EMG and ultrasound guidance. This protocol allows us to train physicians in all aspects of the use of BTX. It also provides us with a cohort of patients, receiving a standard method of treatment and with a stable response to BTX injection, for participation in other protocols on movement disorders and on the responses to BTX injection.
Key facts
- Study ID
- NCT00001208
- Run by
- National Institute of Neurological Disorders and Stroke (NINDS)
- People needed
- 2000
- Starts
- 1989-10-26
- Last updated by the study team
- 2026-08-07
Who can join
Age: 2 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Women who are planning on becoming pregnant, are pregnant or breastfeeding, for the duration of the condition.
- Subjects who require treatment with an aminoglycoside antibiotic, until treatment is complete.
- For laryngeal injections, subjects must have a paradoxical vocal fold movement with intermittent stridor due to either gastroesophageal reflux or emotional disorders
Where it is running
- National Institutes of Health Clinical Center — Bethesda, Maryland, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.