Treatment With Cidofovir for Children With Laryngeal Papillomatosis (Warts in the Throat)

Completed · Phase 1

Conditions studied: Papilloma

In brief

The purpose of this study is to see what dose of the drug cidofovir is safe to treat laryngeal papillomatosis (warts in the throat which occur over and over) in children. Laryngeal papillomatosis is caused by infection with a virus called human papillomavirus (HPV). At present, there is no approved drug to treat this infection. However, cidofovir is a drug effective against several viruses. Cidofovir may be able to attack the HPV virus. This study tests the safety of giving this drug to children.

Key facts

Study ID

NCT00001126

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

36

Expected to finish

2005-11-01

Last updated by the study team

2010-08-27

Who can join

Age: 2 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Your child may be eligible for this study if he/she:
• Has active laryngeal papillomatosis (warts in the throat) that requires 8 or more surgeries per year.
• Developed this infection before the age of 16.
• Is between the ages of 2 and 17 years with consent of parent or guardian.

You may not qualify if…

• Your child will not be eligible for this study if he/she:
• Has a history of a prior malignancy (cancer), kidney disease, or immune system deficiency.
• Is HIV-positive.
• Is allergic to probenecid.
• Has received radiation therapy to the throat area or has received certain medications.
• Is pregnant or breast-feeding.

Where it is running

• NIAID/DMID/CASG Central Unit — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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