Metabolism of Antituberculosis Drugs in HIV-Infected Persons With Tuberculosis

Completed · Not applicable

Conditions studied: HIV Infections, Tuberculosis

In brief

The purpose of this study is to determine if a relationship exists between the level of antituberculosis drugs (isoniazid, rifampin, ethambutol, and pyrazinamide) in the blood and the outcome of HIV-positive patients with tuberculosis. This study also evaluates how these drugs are absorbed and metabolized in the body.

Key facts

Study ID

NCT00000950

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

50

Last updated by the study team

2011-03-02

Who can join

Age: 13 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• You may be eligible for this study if you:
• Are HIV-positive and have tuberculosis.
• Are 13 years of age or older.
• Have written, informed consent of parent or guardian if you are under 18 years of age.
• Agree to practice abstinence or use barrier methods of birth control during the study.

You may not qualify if…

• You will not be eligible for this study if you:
• Have any other disorder or condition which might cause study treatment to be undesirable.
• Are pregnant.

Where it is running

• Univ of Southern California / LA County USC Med Ctr — Los Angeles, California, United States
• Harbor UCLA Med Ctr — Torrance, California, United States
• University of Miami (Pediatric) — Miami, Florida, United States
• Emory Univ — Atlanta, Georgia, United States
• Queens Med Ctr — Honolulu, Hawaii, United States
• Univ of Hawaii — Honolulu, Hawaii, United States
• Tulane Univ School of Medicine — New Orleans, Louisiana, United States
• SUNY / Health Sciences Ctr at Brooklyn — Brooklyn, New York, United States
• Beth Israel Med Ctr — New York, New York, United States
• St Vincent's Hosp / Mem Sloan-Kettering Cancer Ctr — New York, New York, United States
• Mount Sinai Med Ctr — New York, New York, United States
• MetroHealth Med Ctr — Cleveland, Ohio, United States
• Univ of Pennsylvania at Philadelphia — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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